2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK Apoptosis Autophagy
  3. PARP VEGFR DNA/RNA Synthesis Apoptosis Autophagy
  4. PARP/VEGFR3-IN-1

PARP/VEGFR3-IN-1 (Compound 18) 是一种双 PARP-VEGFR3 靶点抑制剂，其对于 PARP1、PARP2 和 VEGFR3 的 IC50 值为 0.0763、0.0366 和 4.25 nM。PARP/VEGFR3-IN-1 对 VEGFR1/2 无抑制，显示亚型选择性。PARP/VEGFR3-IN-1 在多种癌细胞 (白血病、肺癌和三阴性乳腺癌) 中均表现出显著的抗增殖活性。PARP/VEGFR3-IN-1 诱导了 DNA 损伤和细胞周期阻滞。PARP/VEGFR3-IN-1 通过诱导细胞凋亡 (apoptosis) 和自噬 (autophagy) 触发了多种细胞死亡。PARP/VEGFR3-IN-1 可制成纳米制剂，显著提升肿瘤靶向性和治疗窗口。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PARP/VEGFR3-IN-1

PARP/VEGFR3-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PARP/VEGFR3-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP/VEGFR3-IN-1 (Compound 18) is a dual PARP-VEGFR3 target inhibitor. Its IC50 values for PARP1, PARP2, and VEGFR3 are 0.0763, 0.0366, and 4.25 nM respectively. PARP/VEGFR3-IN-1 has no inhibitory effect on VEGFR1/2 and shows subtype selectivity. PARP/VEGFR3-IN-1 exhibits significant anti-proliferative activity in various cancer cells (leukemia, lung cancer, and triple-negative breast cancer). PARP/VEGFR3-IN-1 induces DNA damage and cell cycle arrest. PARP/VEGFR3-IN-1 triggers various forms of cell death by inducing apoptosis and autophagy. PARP/VEGFR3-IN-1 can be formulated into nanodelivery systems, significantly enhancing tumor targeting and therapeutic window[1].

IC50 & Target[1]

PARP1

76.3 pM (IC50)

PARP2

3.66 pM (CC50)

VEGFR3

4.25 nM (IC50)

分子量

700.72

Formula

C38H33FN8O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP/VEGFR3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP/VEGFR3-IN-1PARPVEGFRDNA/RNA SynthesisApoptosisAutophagypoly ADP ribose polymerase Vascular endothelial growth factor receptorPARP inhibitorsVEGFR inhibitorsLeukemiaLung cancerNanoformulationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PARP/VEGFR3-IN-1
目录号：
HY-179020
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z