2. PI3K/Akt/mTOR Apoptosis Cell Cycle/DNA Damage Cytoskeleton
  3. Akt Apoptosis mTOR PI3K Microtubule/Tubulin
  4. PI3K/Akt/mTOR-IN-4

PI3K/Akt/mTOR-IN-4 (compound 4r) 是一种有效的 PI3K/Akt/mTOR 和微管蛋白聚合 (tubulin polymerization) 抑制剂。PI3K/Akt/mTOR-IN-4 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。PI3K/Akt/mTOR-IN-4 会降低p-PI3K、p-Akt、p-mTOR 和 β-微管蛋白的表达。

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PI3K/Akt/mTOR-IN-4 Chemical Structure

PI3K/Akt/mTOR-IN-4 Chemical Structure

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PI3K/Akt/mTOR-IN-4 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent PI3K/Akt/mTOR and tubulin polymerization inhibitor. PI3K/Akt/mTOR-IN-4 induce apoptosis and cell cycle arrest at G2/M phase. PI3K/Akt/mTOR-IN-4 decreases the expression of p-PI3K, p-Akt, and p-mTOR, β-tubulin[1].

体外研究
(In Vitro)

PI3K/Akt/mTOR-IN-4 (compound 4r) (0-100 µM; 48 h) 显示出抗增殖活性，对 SiHa、HeLa、Ca Ski、LO2、HEK-293t 细胞的 IC50 值分别为 3.38、5.03、7.24、21.08、23.96 µM[1]。
PI3K/Akt/mTOR-IN-4 (0-16 µM; 24 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期[1]。
PI3K/Akt/mTOR-IN-4 (4, 8,16 µM；24 h) 以剂量依赖性方式降低 p-PI3K、p-Akt、p-mTOR 和 β-微管蛋白的表达[1]< /sup>。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/Akt/mTOR-IN-4 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SiHa, HeLa, Ca Ski, LO2, HEK-293t cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Inhibited cell proliferative with IC50s of 3.38, 5.03, 7.24, 21.08, 23.96 µM for SiHa, HeLa, Ca Ski, LO2, HEK-293t cells, respectively.

Cell Cycle Analysis[1]

Cell Line: SiHa cells
Concentration: 0-16 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G2/M phase with G2/M phase cells accumulating from 5.24 % (Ctrl) to 28.37 % (16 μM).

Apoptosis Analysis[1]

Cell Line: SiHa cells
Concentration: 0-16 µM
Incubation Time: 24 h
Result: Induced apoptosis the percentage of apoptotic cells were increased from 11.62 % (Ctrl) to 98.56 % (16 μM).

Western Blot Analysis[1]

Cell Line: SiHa cells
Concentration: 4, 8, 16 μM
Incubation Time: 24 h
Result: Decreased the expression of phosphorylation of PI3K, Akt, and mTOR, β-tubulin in a dose-dependent manner.
体内研究
(In Vivo)

PI3K/Akt/mTOR-IN-4 (0-400 μM; 0-96 h) 对斑马鱼胚胎没有毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: zebrafish embryos[1]
Dosage: 0, 12.5, 25, 50, 100, 200, 400 μM
Administration: 0-96 h
Result: Showed no toxicity for zebrafish embryos.
分子量

500.56

Formula

C29H29FN4O3
Unlabeled Cas

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/Akt/mTOR-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/Akt/mTOR-IN-4AktApoptosismTORPI3KMicrotubule/TubulinPKBProtein kinase BMammalian target of RapamycinPhosphoinositide 3-kinasetubulin polymerizationapoptosisG2/Mp-PI3Kp-Aktand p-mTORzebrafish embryosInhibitorinhibitorinhibit

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