Pseudolaric Acid B (Synonyms: 土荆皮乙酸)

目录号: HY-N6939 纯度: 99.31%: Data Sheet SDS COA 产品使用指南
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Pseudolaric Acid B 是一种口服有效的二萜酸。Pseudolaric Acid B 具有抗真菌、抗生育、抗血管生成和抗癌的活性，可诱导肿瘤细胞凋亡 (apoptosis) 和自噬 (autophagy)。此外，Pseudolaric Acid B 可抑制乙肝病毒 (HBV) 分泌和具有免疫抑制的作用，可选择性抑制 T 淋巴细胞的增殖和 IL-2 的产生。

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Pseudolaric Acid B Chemical Structure

CAS No. : 82508-31-4

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1210	In-stock
1 mg	￥305	In-stock
5 mg	￥610	In-stock
10 mg	￥977	In-stock
25 mg	￥1758	In-stock
50 mg	￥2815	In-stock
100 mg	￥4500	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of Pseudolaric Acid B:

Pseudolaric Acid B (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•ACS Infect Dis. 2023 May 4. [Abstract]

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HIF-1α HIF

生物活性
纯度 & 产品资料
参考文献

生物活性

Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target^[3]

HIF-1α

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.3 μM Compound: pseudolaricacid B	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 18651771]
A549	IC₅₀	0.3 μM Compound: pseudolaric acid B	Cytotoxicity against human A549 cells by SRB method Cytotoxicity against human A549 cells by SRB method	[PMID: 17323995]
A549	IC₅₀	0.3 μM Compound: PAB	Cytotoxicity against human A549 cells by SRB method Cytotoxicity against human A549 cells by SRB method	[PMID: 17253850]
A549	IC₅₀	0.86 μg/mL Compound: PAB	Cytotoxicity against human A549 cells after 24 hrs Cytotoxicity against human A549 cells after 24 hrs	[PMID: 15387644]
A549	IC₅₀	1.6 μM Compound: Pseudolaric acid B	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 20038159]
Bel-7402	IC₅₀	> 100 μM Compound: 7	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 17291040]
Bel-7402	IC₅₀	0.704 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against human BEL-7402 cells by SRB assay Antiproliferative activity against human BEL-7402 cells by SRB assay	[PMID: 18078313]
Bel-7402	IC₅₀	1.3 μM Compound: Pseudolaric acid B	Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay	[PMID: 20038159]
BGC-823	IC₅₀	> 100 μM Compound: 7	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 17291040]
HCT-116	IC₅₀	0.136 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 18078313]
HeLa	IC₅₀	0.497 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against human Hela cells by SRB assay Antiproliferative activity against human Hela cells by SRB assay	[PMID: 18078313]
HL-60	IC₅₀	0.235 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against human HL60 cells by SRB assay Antiproliferative activity against human HL60 cells by SRB assay	[PMID: 18078313]
HL-60	IC₅₀	0.59 μM Compound: 7	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 17291040]
HL-60	IC₅₀	4.2 μM Compound: Pseudolaric acid B	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 20038159]
HMEC-1	IC₅₀	0.803 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against HMEC1 cells by SRB assay Antiproliferative activity against HMEC1 cells by SRB assay	[PMID: 18078313]
MDA-MB-468	IC₅₀	0.596 μM Compound: 1, pseudolaric acid B, PAB	Antiproliferative activity against human MB-MDA-468 cells by SRB assay Antiproliferative activity against human MB-MDA-468 cells by SRB assay	[PMID: 18078313]
P388	IC₅₀	0.32 μg/mL Compound: PAB	Cytotoxicity against mouse P388 cells after 24 hrs Cytotoxicity against mouse P388 cells after 24 hrs	[PMID: 15387644]
P388	IC₅₀	0.74 μM Compound: pseudolaric acid B	Cytotoxicity against mouse P388 cells by MTT method Cytotoxicity against mouse P388 cells by MTT method	[PMID: 17323995]
P388	IC₅₀	3.7 μM Compound: PAB	Cytotoxicity against murine P388 cells by MTT method Cytotoxicity against murine P388 cells by MTT method	[PMID: 17253850]

体外研究
(In Vitro)

Pseudolaric Acid B (4 μM; 36 小时-3 天) 能激活 MCF-7 人乳腺癌细胞自噬，防止细胞死亡^[1]。
Pseudolaric Acid B (4 μM; 0-36 小时) 通过诱导细胞凋亡和细胞周期阻滞抑制乙肝病毒 (HBV) 的分泌^[2]。
Pseudolaric Acid B (0.313-10 μM; 6-72 小时) 可以抑制 HUVEC 的增殖、迁移和管形成，以及减少肿瘤细胞分泌 VEGF，这与蛋白酶体介导的 HIF-1α 蛋白降解有关^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	4 μM
Incubation Time:	36 h
Result:	Increased the expression of Beclin-1. Promoted the conversion from LC3-I to LC3-II.

Immunofluorescence^[1]

Cell Line:	MCF-7 cells
Concentration:	4 μM
Incubation Time:	36 h
Result:	Increased the number of autophagic vacuoles.

Western Blot Analysis^[2]

Cell Line:	HepG2215 cells
Concentration:	4 μM
Incubation Time:	0, 6, 12, 24 and 36 h
Result:	Decreased the expression of procaspase-3.

体内研究
(In Vivo)

Pseudolaric Acid B (灌胃; 10-20 mg/kg; 3 天) 在大鼠中具有抗生育的能力，可能与母体的血管系统有关^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

432.46

Formula

C₂₃H₂₈O₈

CAS 号

82508-31-4

性状

固体

颜色

White to off-white

中文名称

土荆皮乙酸

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (115.62 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3124 mL	11.5618 mL	23.1235 mL
5 mM	0.4625 mL	2.3124 mL	4.6247 mL
10 mM	0.2312 mL	1.1562 mL	2.3124 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.78 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.81 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.81 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 50% PEG300 50% Saline
Solubility: 10 mg/mL (23.12 mM); 悬浊液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.47%

选择批次：

Data Sheet (640 KB) SDS (584 KB)

COA (287 KB) HNMR (215 KB) LCMS (120 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737. [Content Brief]

[2]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525. [Content Brief]

[3]. Li MH, et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation. Clin Cancer Res. 2004 Dec 15;10(24):8266-74. [Content Brief]

[4]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90. [Content Brief]

[5]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. [Content Brief]

Pseudolaric Acid B 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3124 mL	11.5618 mL	23.1235 mL	57.8088 mL
	5 mM	0.4625 mL	2.3124 mL	4.6247 mL	11.5618 mL
	10 mM	0.2312 mL	1.1562 mL	2.3124 mL	5.7809 mL
	15 mM	0.1542 mL	0.7708 mL	1.5416 mL	3.8539 mL
	20 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8904 mL
	25 mM	0.0925 mL	0.4625 mL	0.9249 mL	2.3124 mL
	30 mM	0.0771 mL	0.3854 mL	0.7708 mL	1.9270 mL
	40 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
	50 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL
	60 mM	0.0385 mL	0.1927 mL	0.3854 mL	0.9635 mL
	80 mM	0.0289 mL	0.1445 mL	0.2890 mL	0.7226 mL
	100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5781 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pseudolaric Acid B (Synonyms: 土荆皮乙酸)

Customer Review

Other Forms of Pseudolaric Acid B:

MCE 顾客使用本产品发表的 1 篇科研文献