1. PROTAC Protein Tyrosine Kinase/RTK
  2. PROTACs Btk
  3. SJF620 hydrochloride

SJF620 hydrochloride 是一种由Cereblon配体和Btk配体相连的PROTAC,DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物,可募集 CRBN。

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SJF620 hydrochloride Chemical Structure

SJF620 hydrochloride Chemical Structure

CAS No. : 2821938-05-8

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1 mg ¥2320
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5 mg ¥5800
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10 mg ¥9800
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SJF620 hydrochloride 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

797.30

Formula

C41H45ClN8O7

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

SJF620 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SJF620 hydrochloride
目录号:
HY-133137A
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