2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. SK2187

SK2187 是一种具有选择性的 AURKA PROTAC降解剂，其 DC50 值约为 10 nM。SK2187 对 NGP 细胞表现出生长抑制作用，其 IC50 值为 101.5 nM。SK2187 可用于研究 MYCN 扩增型神经母细胞瘤。(粉色：AURKA 配体：MK-5108 (HY-13252)；蓝色：E3 配体 (HY-103597) ；黑色：连接子：Amino-PEG3-alcohol (HY-W015088))。

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SK2187

SK2187 Chemical Structure

CAS No. : 3038446-91-9

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SK2187 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088))[1].

体外研究
(In Vitro)

SK2187 (10-1000 nM, 24 h) 能够剂量依赖性降解 AURKA 蛋白，其 DC50 值约为 10 nM，Dmax 为 85%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SK2187 相关抗体:
分子量

950.43

Formula

C45H49ClFN7O11S
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

SK2187 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK21873038446-91-9JB301SK 2187SK-2187JB 301JB-301PROTACsAurora KinaseAURKANeuroblastomaPROTACMYCNTargeted protein degradationInhibitorinhibitorinhibit

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HY-171768
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