2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel iGluR Calcium Channel
  4. TAT-EE3

TAT-EE3 是一种神经保护肽，可使 TRPM2 与 NMDARs 的相互作用解偶联。TAT-EE3 抑制 TRPM2 诱导的 NMDAR 表面表达和电流幅度增强。TAT-EE3 在体外和体内均可保护神经元免受缺血性损伤。TAT-EE3 可用于缺血性中风的研究。

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Custom Peptide Synthesis

TAT-EE3

TAT-EE3 Chemical Structure

CAS No. : 2899218-49-4

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TAT-EE3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke[1].

体外研究
(In Vitro)

TAT-EE3 (10 μM, 过夜) 破坏了 HEK293T 细胞和神经元中 TRPM2 与 GluN2a/GluN2b 之间的相互作用，抑制了 TRPM2 诱导的 NMDA 受体表面表达增强和电流振幅增大[1]。
TAT-EE3 (10 μM, 过夜) 减少了野生型神经元中氧糖剥夺 (OGD) 诱导的细胞内 Ca2+ 超载、神经元死亡和线粒体去极化，但对全局 TRPM2 敲除 (gM2KO) 神经元无影响[1]。
TAT-EE3 (10 μM, 30-90 min) 消除了野生型神经元中 PMA 诱导的 NMDA 受体电流增强，对 gM2KO 神经元无额外抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-EE3 相关抗体:
体内研究
(In Vivo)

TAT-EE3 (0.33 mg/kg (100 nmol/kg)，腹腔注射，大脑中动脉闭塞 (MCAO) 前 15 分钟或 MCAO 后每 12 小时重复注射，持续 7 天) 减小了野生型小鼠的梗死体积并改善了其神经功能缺损评分，但在神经元特异性 TRPM2 敲除 (nM2KO) 小鼠中未显示出进一步的保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Focal cerebral ischemia models were constructed by performing right middle cerebral artery occlusion (MCAO) on 8-9 week-old male mice, with 120 minutes of occlusion followed by 24 hours of reperfusion, or 60 minutes of occlusion followed by 7 days of reperfusion[1]
Dosage: 0.33 mg/kg (100 nmol/kg)
Administration: i.p. repeated every 12 h after MCAO for 7 days
Result: Reduced infarct volume.
Inhibited MCAO-induced increase in NMDAR surface expression in wild-type mice, but did not exert further Protective effects in neuron-specific TRPM2 knockout (nM2KO) mice.
Improved long-term neurological deficit scores and rotarod test performance in mice.
Maintained the phosphorylation levels of ERK1/2 and CREB in the brain.
分子量

3339.61

Formula

C135H228N48O49S
CAS 号
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Glu-Asp-Thr-Asp-Ser-Ser-Glu-Glu-Met-Leu-Ala-Leu-Ala-Glu-Glu
Sequence Shortening

YGRKKRRQRRREEDTDSSEEMLALAEE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-EE3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-EE32899218-49-4TRP ChanneliGluRCalcium ChannelTransient receptor potential channelsIonotropic glutamate receptorsCa2+ channelsCa channelsneuroprotective peptideTRPM2NMDARsischemic strokeInhibitorinhibitorinhibit

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