2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 18

TLR7 agonist 18 (Compound 21a) 是一种选择性的 Toll-样受体 7 (TLR7) 激动剂 EC50 为 7.8 μM。TLR7 agonist 18 对 hTLR7 基因共转染的 HEK293 细胞系无细胞毒性，并且可以诱导几种细胞因子的分泌，包括 IL-1β、IL-12p70、IL-8 和 TNF-α。TLR7 agonist 18 可以用于疫苗、哮喘、过敏和抗癌的研究。

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TLR7 agonist 18 Chemical Structure

TLR7 agonist 18 Chemical Structure

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TLR7 agonist 18 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research[1].

IC50 & Target

EC50: 7.8 μM (TLR7)[1].
分子量

380.34

Formula

C18H16F4N4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLR7 agonist 18 相关分类

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  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 18Toll-like Receptor (TLR)Vaccinesasthmaallergiesanti-cancerimmune regulationIL-1βIL-12p70IL-8TNF-αInhibitorinhibitorinhibit

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产品名称：
TLR7 agonist 18
目录号：
HY-162116
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