1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU-29

VU-29 

目录号: HY-107508
产品使用指南

VU-29 是代谢型谷氨酸 5 (mGlu5) 受体的正变构调节剂 (对 rmGluR5 的 EC50=9 nM, Ki=244 nM)。相对于其他亚型,VU-29 对 mGluR5 具有选择性 (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM)。

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VU-29 Chemical Structure

VU-29 Chemical Structure

CAS No. : 890764-36-0

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Description

VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM and Ki=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM)[1][2].

IC50 & Target[1][2]

rat mGluR5

9 nM (EC50)

rat mGluR1

557 nM (EC50)

rat mGluR2

1.5 μM (EC50)

hmGluR4

154 nM (EC50)

rat mGluR5

224 nM (Ki)

In Vivo

VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 µM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 µM) potentiates stimulus-induced NMDA receptor-independent LTD[1].

Molecular Weight

384.39

Formula

C₂₂H₁₆N₄O₃

CAS No.

890764-36-0

SMILES

O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3)C4=CC=C([N+]([O-])=O)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
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Keywords:

VU-29VU29VU 29mGluRMetabotropic glutamate receptorsLTPLTDallostericpotentiatorrathippocampalInhibitorinhibitorinhibit

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产品名称:
VU-29
目录号:
HY-107508
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