1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. 16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2 (Synonyms: 16,16-dimethyl PGE2)

目录号: HY-106420
产品使用指南

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) 是一种具有口服活性的脊椎动物造血干细胞 (HSCs) 稳态关键调节剂。16,16-Dimethyl prostaglandin E2 可以通过 EP2/EP4 起作用,并与 Wnt 途径相互作用。

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16,16-Dimethyl prostaglandin E2 Chemical Structure

16,16-Dimethyl prostaglandin E2 Chemical Structure

CAS No. : 39746-25-3

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Description

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].

IC50 & Target

EP2

 

EP4

 

In Vivo

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 µg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2IMF-KO mice and restores epithelial proliferation and structure[2].

Animal Model: Tpl2IMF-KO mice[2]
Dosage: 10 µg/kg
Administration: IP; every 12 hours; for 8 days
Result: Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
Molecular Weight

380.52

Formula

C₂₂H₃₆O₅

CAS No.

39746-25-3

SMILES

CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(C[C@H]1O)=O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

16,16-Dimethyl prostaglandin E216,16-dimethyl PGE2Prostaglandin ReceptorOrallyHematopoieticstemcellsHSCshomeostasisregulatorInhibitorinhibitorinhibit

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产品名称:
16,16-Dimethyl prostaglandin E2
目录号:
HY-106420
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