2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase PGE synthase
  4. 5-LO/mPGES1-IN-1

5-LO/mPGES1-IN-1 (Compound 16) 是一种微粒体前列腺素 E2 合成酶-1 (mPGES-1) 和 5-脂氧合酶 (5-LO) 双重抑制剂，IC50 值分别为 0.3 和 0.4 μM。5-LO/mPGES1-IN-1 具有抗炎活性。

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5-LO/mPGES1-IN-1 Chemical Structure

5-LO/mPGES1-IN-1 Chemical Structure

CAS No. : 1492060-44-2

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5-LO/mPGES1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

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5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity[1].

IC50 & Target

5-LOX

0.4 μM (IC50)

体内研究
(In Vivo)

5-LO/mPGES1-IN-1 (10 mg/kg, 腹腔注射, 腹膜炎诱导前 30 分钟预处理) 在 zymosan 诱导的小鼠腹膜炎模型中，可降低血管通透性和炎症细胞浸润，并伴有半胱氨酸-白三烯和前列腺素 E2 水平受损[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan-Induced Peritonitis in Mice[1]
Dosage: 10 mg/kg
Administration: i.p. pretreated 30 minutes before peritonitis induction
Result: Reduced vascular permeability by 57% and inhibited neutrophil infiltration by 45%.
分子量

513.07

Formula

C25H25ClN4O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-LO/mPGES1-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

5-LO/mPGES1-IN-11492060-44-2LipoxygenasePGE synthaseLOXProstaglandin E synthase5-LOmPGES-1InhibitorZymosan-Induced Peritonitis in MiceAnti-inflammatoryinhibitorinhibit

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