1. Anti-infection
  2. Beta-lactamase Bacterial Antibiotic
  3. Avibactam sodium hydrate

Avibactam sodium hydrate  (Synonyms: 阿维巴坦钠水合物; NXL-104 hydrate)

目录号: HY-14879B
产品使用指南

Avibactam sodium (NXL-104) hydrate 是一种共价的、可逆的非 β-内酰胺 β-内酰胺酶抑制剂 (β-lactamase) 抑制剂,抑制 β-lactamase TEM-1CTX-M-15IC50 分别为 8 nM 和 5 nM。

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Avibactam sodium hydrate Chemical Structure

Avibactam sodium hydrate Chemical Structure

CAS No. : 2938989-90-1

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10 mM * 1 mL in Water ¥839
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2 mg ¥500
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5 mg ¥650
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10 mg ¥950
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50 mg ¥2600
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100 mg ¥3800
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200 mg ¥7200
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1 g   询价  

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Other Forms of Avibactam sodium hydrate:

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Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 56 篇科研文献

Proliferation Assay

    Avibactam sodium hydrate purchased from MCE. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.  [Abstract]

    Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

    IC50 & Target

    IC50: 5 nM (CTX-M-15), 8 nM (TEM-1)[1]

    体外研究
    (In Vitro)

    Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases[2].
    Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8 mg/L[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model[3].
    Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model[4]
    Dosage: 0.375 mg/g in combination with Ceftazidime
    Administration: Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
    Result: 70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
    Clinical Trial
    分子量

    305.24

    Formula

    C7H12N3NaO7S

    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    阿维巴坦钠水合物

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : ≥ 200 mg/mL (655.22 mM)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.2761 mL 16.3806 mL 32.7611 mL
    5 mM 0.6552 mL 3.2761 mL 6.5522 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂: PBS

      Solubility: 25 mg/mL (81.90 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料
    参考文献

    Avibactam sodium hydrate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.2761 mL 16.3806 mL 32.7611 mL 81.9028 mL
    5 mM 0.6552 mL 3.2761 mL 6.5522 mL 16.3806 mL
    10 mM 0.3276 mL 1.6381 mL 3.2761 mL 8.1903 mL
    15 mM 0.2184 mL 1.0920 mL 2.1841 mL 5.4602 mL
    20 mM 0.1638 mL 0.8190 mL 1.6381 mL 4.0951 mL
    25 mM 0.1310 mL 0.6552 mL 1.3104 mL 3.2761 mL
    30 mM 0.1092 mL 0.5460 mL 1.0920 mL 2.7301 mL
    40 mM 0.0819 mL 0.4095 mL 0.8190 mL 2.0476 mL
    50 mM 0.0655 mL 0.3276 mL 0.6552 mL 1.6381 mL
    60 mM 0.0546 mL 0.2730 mL 0.5460 mL 1.3650 mL
    80 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0238 mL
    100 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.8190 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    Avibactam sodium hydrate
    目录号:
    HY-14879B
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