2. Cytoskeleton Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin ADC Cytotoxin
  4. MMAF-d8 hydrochloride

MMAF-d8 hydrochloride 

目录号: HY-15579AS 纯度: 99.70%
COA 产品使用指南

摩尔计算器

MMAF-d8 (hydrochloride)e是MMAF hydrochloride的氘代形式。

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MMAF-d<sub>8</sub> hydrochloride Chemical Structure

MMAF-d8 hydrochloride Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥9180
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of MMAF-d8 hydrochloride:

MMAF-d8 hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 ADC Cytotoxin 亚型特异性产品:

查看所有亚型
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

IC50 & Target

Auristatin

 

体外研究
(In Vitro)

MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMAF-d8 hydrochloride 相关抗体:
体内研究
(In Vivo)

The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

776.47

Formula

C39H58D8ClN5O8
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (128.79 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2879 mL 6.4394 mL 12.8788 mL
5 mM 0.2576 mL 1.2879 mL 2.5758 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

Cells are treated with serial dilutions of test molecules and incubated 4-6 days depending on cell line. Assessment of cellular growth and data reduction to generate IC50 values is done using Alamar Blue dye reduction assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice: When subcutaneous Karpas 299 tumor size reaches 300 mm3, three animals per group receives one injection of 10 mg antibody component/kg body weight of either cAC10-L1-MMAF4 or cBR96-L1-MMAF4 intravenously. Tumors are then removed and placed in optimal cutting temperature compound, and 5 μm-thin frozen tissue sections are stained using immunohistochemistry evaluation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

MMAF-d8 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2879 mL 6.4394 mL 12.8788 mL 32.1970 mL
5 mM 0.2576 mL 1.2879 mL 2.5758 mL 6.4394 mL
10 mM 0.1288 mL 0.6439 mL 1.2879 mL 3.2197 mL
15 mM 0.0859 mL 0.4293 mL 0.8586 mL 2.1465 mL
20 mM 0.0644 mL 0.3220 mL 0.6439 mL 1.6098 mL
25 mM 0.0515 mL 0.2576 mL 0.5152 mL 1.2879 mL
30 mM 0.0429 mL 0.2146 mL 0.4293 mL 1.0732 mL
40 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8049 mL
50 mM 0.0258 mL 0.1288 mL 0.2576 mL 0.6439 mL
60 mM 0.0215 mL 0.1073 mL 0.2146 mL 0.5366 mL
80 mM 0.0161 mL 0.0805 mL 0.1610 mL 0.4025 mL
100 mM 0.0129 mL 0.0644 mL 0.1288 mL 0.3220 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAF-d8Microtubule/TubulinADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-15579AS
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