2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. EPAC 5376753

EPAC 5376753 是一种 2-Thiobarbituric acid (HY-77962) 衍生物，是一种选择性变构 Epac 抑制剂。EPAC 5376753 在 Swiss 3T3 细胞中抑制 Epac1，IC50 为 4 µM。EPAC 5376753 不抑制 PKA 和腺苷酸环化酶。

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EPAC 5376753

EPAC 5376753 Chemical Structure

CAS No. : 302826-61-5

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规格 价格 是否有货 数量
1 mg ￥700
In-stock
5 mg ￥1588
In-stock
10 mg ￥2320
In-stock
25 mg ￥4095
In-stock
50 mg ￥5650
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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EPAC 5376753 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EPAC 5376753, a 2-Thiobarbituric acid (HY-77962) derivative, is a selective and allosteric Epac inhibitor. EPAC 5376753 inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. EPAC 5376753 does not inhibit PKA and adenylyl cyclases[1].

IC50 & Target

IC50: 4 µM (Epac)[1]
体外研究
(In Vitro)

EPAC 5376753 (1-100 μM；48 小时) 浓度高于 50 μM 时会显著抑制细胞活性，低于 50 μM 时则对细胞活性无影响[1]。
Epac 是 cAMP 信号传导的关键介质。EPAC 5376753 选择性抑制 Epac 介导的成纤维细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EPAC 5376753 相关抗体:

Cell Viability Assay[1]

Cell Line: Swiss 3T3 cells
Concentration: 1 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM
Incubation Time: 48 h
Result: <50 μM of compound did not significantly decrease viability.
>50 μM significantly inhibited cell activity.
分子量

367.21

Formula

C15H8Cl2N2O3S
CAS 号
性状

固体

颜色

Orange to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

EPAC 5376753 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPAC 5376753302826-61-5EPAC5376753EPAC-5376753RasInhibitorinhibitorinhibit

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产品名称：
EPAC 5376753
目录号：
HY-111446
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