2. Stem Cell/Wnt Apoptosis Autophagy
  3. Wnt Apoptosis Autophagy
  4. Ginkgetin

Ginkgetin  (Synonyms: 银杏双黄酮)

目录号: HY-N0889 纯度: 99.86%
COA 产品使用指南

摩尔计算器

Ginkgetin 是一种从银杏叶中分离得到的双黄酮。Ginkgetin 具有抗肿瘤，抗炎，神经保护，抗真菌的作用。Ginkgetin 也是一种有效的 Wnt 信号抑制剂，IC50 值为 5.92 μM。

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Ginkgetin Chemical Structure

Ginkgetin Chemical Structure

CAS No. : 481-46-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1869
In-stock
1 mg ￥571
In-stock
5 mg ￥1500
In-stock
10 mg ￥2400
In-stock
25 mg ￥5300
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ginkgetin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

体外研究
(In Vitro)

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells[2].
? Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner[3].
? Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells[2].
? Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner[1].
? Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ginkgetin 相关抗体:

Cell Viability Assay[2]

Cell Line: Daoy and D283 cell lines
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

Apoptosis Analysis[3]

Cell Line: Osteosarcoma cells
Concentration: 20, 30, 40 μM
Incubation Time: 24 hours
Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

Cell Cycle Analysis[2]

Cell Line: Daoy cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 24 hours
Result: Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.

Cell Cycle Analysis[2]

Cell Line: Daoy and D283 cell lines
Concentration: 10, 20 μM
Incubation Time: 3, 6, 12, 24 hours
Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.
体内研究
(In Vivo)

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
? Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g)[4]
Dosage: 25, 50, 100 mg/kg
Administration: I.p. 2 hours after the onset of ischemia
Result: Reduced the neurological deficit score.
Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
Decreased the expressions of ICAM-1, COX-2, and iNOS.
Downregulated downstream inflammatory factor PGE2 and TNF-α expression.
Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
分子量

566.51

Formula

C32H22O10
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

银杏素；白果双黄酮；银杏双黄酮；银杏黄素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 20.83 mg/mL (36.77 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7652 mL 8.8260 mL 17.6519 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 50% PEG300    50% Saline

    Solubility: 2 mg/mL (3.53 mM); 悬浊液; 超声加热助溶

  • 方案 二

    请依序添加每种溶剂： 0.5% CMC-Na/saline water

    Solubility: 2 mg/mL (3.53 mM); 悬浊液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.86%

COA (194 KB) HNMR (301 KB) LCMS (264 KB)

产品使用指南 (1538 KB)
参考文献

Ginkgetin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7652 mL 8.8260 mL 17.6519 mL 44.1298 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL 8.8260 mL
10 mM 0.1765 mL 0.8826 mL 1.7652 mL 4.4130 mL
15 mM 0.1177 mL 0.5884 mL 1.1768 mL 2.9420 mL
20 mM 0.0883 mL 0.4413 mL 0.8826 mL 2.2065 mL
25 mM 0.0706 mL 0.3530 mL 0.7061 mL 1.7652 mL
30 mM 0.0588 mL 0.2942 mL 0.5884 mL 1.4710 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ginkgetin481-46-9银杏素白果双黄酮银杏双黄酮银杏黄素WntApoptosisAutophagybiflavoneGinkgobilobaleavesanti-tumoranti-inflammatoryneuroprotectiveanti-fungalsignalingInhibitorinhibitorinhibit

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