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  3. LY2940094 tartrate

LY2940094 tartrate  (Synonyms: BTRX-246040 tartrate)

目录号: HY-114452A
产品使用指南

LY2940094 (BTRX-246040) tartrate 是一种高效、可透过大脑的、选择性、口服的 NOP 受体拮抗剂,具有高亲和力 (Ki=0.105 nM) 和拮抗作用 (Kb=0.166 nM)。LY2940094 tartrate 可减少动物模型中的乙醇自我给药和寻求乙醇。

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LY2940094 tartrate Chemical Structure

LY2940094 tartrate Chemical Structure

CAS No. : 1307245-87-9

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生物活性

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1].

IC50 & Target

Ki: 0.105 nM (NOP receptor)[1]
Kb: 0.166 nM (NOP receptor)[1]

体内研究
(In Vivo)

LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1]
Dosage: 3, 10, or 30 mg/kg
Administration: P.o.; daily for 4 days
Result: Reduced homecage ethanol self-administration.
Clinical Trial
分子量

631.05

Formula

C26H29ClF2N4O8S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

LY2940094 tartrate 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LY2940094 tartrate
目录号:
HY-114452A
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