2. Immunology/Inflammation Apoptosis
  3. COX Apoptosis
  4. Metamizole sodium

Metamizole sodium  (Synonyms: 安乃近; Dipyrone)

目录号: HY-B1279A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Metamizole sodium (Dipyrone) 是一种有口服活性的环氧合酶 (COX) 抑制剂。Metamizole sodium 可抑制细胞增殖，促进细胞凋亡。Metamizole sodium 有抗炎和抗氧化活性。Metamizole sodium 是一种解热镇痛解痉剂。Metamizole sodium 可用于缓解各种疼痛的研究。

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Metamizole sodium Chemical Structure

Metamizole sodium Chemical Structure

CAS No. : 68-89-3

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Other Forms of Metamizole sodium:

Metamizole sodium 相关抗体

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  • 生物活性

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生物活性

Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain[1][2][3][4][5].

IC50 & Target

COX-3[2]
体外研究
(In Vitro)

Metamizole sodium (1 和 10 μM, 24 h) 可抑制成骨细胞分化过程，从而降低其产生新的骨矿化细胞外基质的能力[2]。
Metamizole sodium (1-500 μM, 48 h) 在胰腺癌细胞系 PaTu 8988 t 和 Panc-1 中可抑制细胞增殖，促进细胞凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metamizole sodium 相关抗体:

Cell Proliferation Assay[3]

Cell Line: PaTu 8988 t, Panc-1
Concentration: 1, 10, 100, 250, 500 μM
Incubation Time: 48 hours
Result: Inhibited proliferation in the PaTu 8988 t cell line with 1–500 μM and with concentrations of 1 μM, 10 μM, 100 μM, and 250 μM in the Panc-1 cell line.
Increased the apoptosis rate after 9 h.
体内研究
(In Vivo)

Metamizole sodium (500 mg/kg, 腹腔注射, 一天两次连续7 天) 可减少大鼠神经性疼痛症状的发展[4]。
Metamizole sodium (250 或 500 mg/kg, 口服 ) 可有效缓解大鼠刀切和卡拉胶诱导的疼痛和氧化应激反应[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (270-300 g), with peripheral neuropathic pain[4]
Dosage: 500 mg/kg
Administration: Intraperitoneal injection, twice a day, for 7 days
Result: Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.
Animal Model: Pain model in rats [5]
Dosage: 250 or 500 mg/kg
Administration: p.o.
Result: Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression. Reduced MDA levels in the carrageenan paw test and increased tGSH levels.
Clinical Trial
分子量

333.34

Formula

C13H16N3NaO4S
CAS 号
性状

固体

颜色

White to off-white

中文名称

安乃近
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

COA (196 KB) HNMR (203 KB)

产品使用指南 (1538 KB)
参考文献

Metamizole sodium 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metamizole68-89-3Dipyrone安乃近COXApoptosisCyclooxygenaseInhibitorPancreatic carcinomaProliferationNeuropathic pain rat modelinhibitorinhibit

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