2. Cell Cycle/DNA Damage Autophagy Anti-infection
  3. Topoisomerase Autophagy Bacterial Antibiotic
  4. Pirarubicin

Pirarubicin  (Synonyms: 吡柔比星; THP)

目录号: HY-13725 纯度: 98.56%
COA 产品使用指南

摩尔计算器

Pirarubicin (THP) 是一种蒽环类抗生素，为拓扑异构酶 II (topoisomerase II) 的抑制剂，可用于各种癌症尤其是实体瘤的研究。

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Pirarubicin Chemical Structure

Pirarubicin Chemical Structure

CAS No. : 72496-41-4

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规格 价格 是否有货 数量
5 mg ￥343
In-stock
10 mg ￥523
In-stock
25 mg ￥1176
In-stock
50 mg ￥1999
In-stock
100 mg ￥3713
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Pirarubicin:

Pirarubicin 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

IC50 & Target[1]

Topoisomerase II

 

体外研究
(In Vitro)

Pirarubicin is a topoisomerase II inhibitor[1]. Pirarubicin shows inhibitory activities against M5076 and Ehrlich cells, with IC50s of 0.366 and 0.078 μM, respectively. The cytotoxicity of Pirarubicin toward M5076 cells is lower than toward Ehrlich cells, and this is due to the much lower expression of topoisomerase II in M5076 cells than in Ehrlich cells[2]. Pirarubicin (2.5, 5, 10 μg/mL) significantly induces autophagy in a dose dependent manner in bladder cancer (T24, EJ, 5637, J82 and UM-UC-3) cells. Furthmore, Pirarubicin (5 μg/mL) induces apoptosis through inhibition of mTOR/p70S6K/4E-BP1 in bladder cancer cells, and this effect is enhanced by inhibition of autophagy[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pirarubicin 相关抗体:
体内研究
(In Vivo)

Pirarubicin (18 mg/kg, i.v.) significantly elevates serum level of BNP, CK-MB, CTnT, LDH, and MDA compared with those in the control group in acute cardiac toxicity rats. Pirarubicin also lowers heart rate, and depresses R-wave voltage, and prolongation of QT intervals in the acute cardiac toxicity model[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

627.64

Formula

C32H37NO12
CAS 号
性状

固体

颜色

Pink to red

中文名称

吡柔比星；吡喃阿霉素；吡柔吡星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (15.93 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5933 mL 7.9664 mL 15.9327 mL
5 mM 0.3187 mL 1.5933 mL 3.1865 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.61%

COA (205 KB) HNMR (209 KB) LCMS (314 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[3]

MTS is used to analyze cell survival. Briefly, cells are plated in 96-well plates in triplicate at 2 × 103 cells per well and cultured in growth medium. Then cells are treated with pirarubicin at different concentrations (2.5 μg/mL, 5 μg/mL, 10 μg/mL) for 24 h. MTS reagent (5 mg/mL) is added and incubated at 37°C for 4 h. The absorbance is monitored at 490 nm using a microplate reader[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

An acute cardiac toxicity model is established by a single dose of 18 mg/kg pirarubicin through the caudal vein injection. Thirty-six rats are randomized equally to six groups: normal control, cardiac injury (THP) model, dexrazoxane (180 mg/kg), low-dose rutin (25 mg/kg), middle-dose rutin (50 mg/kg), and high-dose rutin (100 mg/kg). Rats in the rutin-treated group are administered different doses of rutin and CMC-Na for 7 days by gavage and a single dose of 18 mg/kg pirarubicin through caudal vein injection. Rats in the dexrazoxane-treated group receive sodium carboxymethylcellulose (CMC-Na) by gavage for six days. 40 mg/kg dexrazoxane is then administered to rats by intraperitoneal injection and 18 mg/kg pirarubicin is administered by caudal vein injection on day 7. Rats in the THP model group receive CMC-Na by gavage for seven days, followed by pirarubicin 18 mg/kg through the caudal vein injection on day 7. Rats in the normal control group receive CMC-Na by gavage for seven days, followed by saline through caudal vein injection on day 7[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Pirarubicin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5933 mL 7.9663 mL 15.9327 mL 39.8317 mL
5 mM 0.3187 mL 1.5933 mL 3.1865 mL 7.9663 mL
10 mM 0.1593 mL 0.7966 mL 1.5933 mL 3.9832 mL
15 mM 0.1062 mL 0.5311 mL 1.0622 mL 2.6554 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pirarubicin72496-41-4THP吡柔比星吡喃阿霉素吡柔吡星TopoisomeraseAutophagyBacterialAntibioticInhibitorinhibitorinhibit

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