2. Neuronal Signaling
  3. Legumain
  4. RR-11a

RR-11a是人工合成的天冬酰胺酰内肽酶 Legumain 抑制剂 (IC50=31-55 nM)。RR-11a 可用于癌症和急性心肌梗死 (AMI) 的研究。

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RR-11a Chemical Structure

RR-11a Chemical Structure

CAS No. : 1361390-56-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1689
In-stock
5 mg ￥1370
In-stock
10 mg ￥2050
In-stock
25 mg ￥4100
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of RR-11a:

RR-11a 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI)[1][2][3].

IC50 & Target[2]

Legumain

31-55 nM (IC50)

体外研究
(In Vitro)

Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RR-11a 相关抗体:
体内研究
(In Vivo)

Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
RR-11a (20 mg/kg; daily i.p. for 30 days) improves cardiac function, decreases cardiac rupture rate, and attenuates left chamber dilation and wall thinning post-AMI in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

560.51

Formula

C24H28N6O10
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (178.41 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7841 mL 8.9204 mL 17.8409 mL
5 mM 0.3568 mL 1.7841 mL 3.5682 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 81.51%

COA (283 KB) HNMR (258 KB) LCMS (99 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Mice[1]

Mice bearing 4T1 orthothopic tumors of approximately 500 mm3 are injected once intravenously with RR-11a+ or RR-11a-nanoparticles labeled with rhodamine B. Alternatively, mice are injected intravenously 3 times at 48-hour intervals with RDZ-218, NP-DOX, free DOX, or saline. Twenty-four hours after the final treatment, animals are sacrificed and spleen, kidney, lungs, liver, heart and tumor are collected, frozen in OCT compound, immediately sectioned and imaged by fluorescence microscopy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

RR-11a 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7841 mL 8.9204 mL 17.8409 mL 44.6022 mL
5 mM 0.3568 mL 1.7841 mL 3.5682 mL 8.9204 mL
10 mM 0.1784 mL 0.8920 mL 1.7841 mL 4.4602 mL
15 mM 0.1189 mL 0.5947 mL 1.1894 mL 2.9735 mL
20 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2301 mL
25 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7841 mL
30 mM 0.0595 mL 0.2973 mL 0.5947 mL 1.4867 mL
40 mM 0.0446 mL 0.2230 mL 0.4460 mL 1.1151 mL
50 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8920 mL
60 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7434 mL
80 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5575 mL
100 mM 0.0178 mL 0.0892 mL 0.1784 mL 0.4460 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RR-11a1361390-56-8LegumainAsparaginyl endopeptidaseδ-secretasemicecanceracute myocardial infarctioncardiac functionsyntheticInhibitorinhibitorinhibit

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