1. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Anti-infection Apoptosis
  2. Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis
  3. Suramin

Suramin 是一种可逆的,竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin 是有效的 sirtuins 抑制剂:SirT1 (IC50=297 nM),SirT2 (IC50=1.15 μM),SirT5 (IC50=22 μM)。Suramin 是竞争性逆转录酶抑制剂 (DNA topoisomerase II: IC50=5 μM)。Suramin 是一种有效的 SARS-CoV-2 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。Suramin 有效抑制 IP5K,并且是抗寄生虫 (antiparasitic),抗肿瘤和抗血管生成剂。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Suramin sodium salt 通常具有更好的水溶性和稳定性。

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Suramin Chemical Structure

Suramin Chemical Structure

CAS No. : 145-63-1

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Top Publications Citing Use of Products

    Suramin purchased from MCE. Usage Cited in: J Biol Chem. 2020 Jul 24;295(30):10281-10292.  [Abstract]

    Suramin inhibits IP5K function in vivo. Immunoprecipitation of myc-CSN2 from myc-CSN2-HEK293 stable cell after IP5K knockdown, with or without Suramin or NF449 treatment.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5].Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].

    IC50 & Target[2]

    SIRT1

    297 nM (IC50)

    SIRT2

    1.15 μM (IC50)

    SIRT5

    22 μM (IC50)

    体外研究
    (In Vitro)

    Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[7].
    Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells[7].
    Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[8].
    The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[7].
    Suramin blocks viral replication in Vero E6 cells[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[6]

    Cell Line: HO-8910 PM ovarian and Hela cervical cancer cells
    Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL
    Incubation Time: For 24, 48, 72 and 96 hours
    Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner.

    Apoptosis Analysis[6]

    Cell Line: HeLa cells
    Concentration: 300 μg/mL
    Incubation Time: For 48 hours
    Result: Induced cells apoptosis.

    Western Blot Analysis[7]

    Cell Line: PA-SMCs cells
    Concentration: 1 mg/mL
    Incubation Time: For 1 hours
    Result: Significantly suppressed the phosphorylated ERK1/2.
    体内研究
    (In Vivo)

    Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[8].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Wistar rats (200-225 g)[7]
    Dosage: 10 mg/kg
    Administration: IV; twice weekly for 3 weeks
    Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
    Clinical Trial
    分子量

    1297.28

    Formula

    C51H40N6O23S6

    CAS 号
    中文名称

    苏拉明

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    目录号:
    HY-B0879
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