2. Protein Tyrosine Kinase/RTK Neuronal Signaling GPCR/G Protein
  3. DYRK 5-HT Receptor
  4. Harmine hydrochloride

Harmine hydrochloride  (Synonyms: 哈尔碱盐酸盐; Telepathine hydrochloride)

目录号: HY-N0737 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Harmine Hydrochloride (Telepathine Hydrochloride) 是一种具有抗癌和抗炎活性的 DYRK 抑制剂。Harmine Hydrochloride 对 5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。

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Harmine hydrochloride Chemical Structure

Harmine hydrochloride Chemical Structure

CAS No. : 343-27-1

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规格 价格 是否有货 数量
50 mg ￥500
In-stock
100 mg ￥800
In-stock
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500 mg   询价  

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Customer Review

Other Forms of Harmine hydrochloride:

Harmine hydrochloride 相关抗体

Top Publications Citing Use of Products

    Harmine hydrochloride purchased from MCE. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267.  [Abstract]

    Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.

    查看 DYRK 亚型特异性产品:

    查看所有亚型
    DYRK1 DYRK2 DYRK4

    查看 5-HT Receptor 亚型特异性产品:

    查看所有亚型
    5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

    IC50 & Target[1]

    5-HT2A Receptor

    397 nM (Ki)

    DYRK1A

     

    体外研究
    (In Vitro)

    Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Harmine hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    248.71

    Formula

    C13H13ClN2O
    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    中文名称

    哈尔碱盐酸盐
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 10 mg/mL (40.21 mM; 超声助溶 (<60°C))

    DMSO 中的溶解度 : 5 mg/mL (20.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.0207 mL 20.1037 mL 40.2075 mL
    5 mM 0.8041 mL 4.0207 mL 8.0415 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.93%

    COA (192 KB) HNMR (258 KB) LCMS (92 KB)

    产品使用指南 (1538 KB)
    参考文献

    Harmine hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 4.0207 mL 20.1037 mL 40.2075 mL 100.5187 mL
    5 mM 0.8041 mL 4.0207 mL 8.0415 mL 20.1037 mL
    10 mM 0.4021 mL 2.0104 mL 4.0207 mL 10.0519 mL
    15 mM 0.2680 mL 1.3402 mL 2.6805 mL 6.7012 mL
    20 mM 0.2010 mL 1.0052 mL 2.0104 mL 5.0259 mL
    H2O 25 mM 0.1608 mL 0.8041 mL 1.6083 mL 4.0207 mL
    30 mM 0.1340 mL 0.6701 mL 1.3402 mL 3.3506 mL
    40 mM 0.1005 mL 0.5026 mL 1.0052 mL 2.5130 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Harmine343-27-1Telepathine哈尔碱盐酸盐DYRK5-HT ReceptorDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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    目录号：
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