2. Anti-infection
  3. Antibiotic Fungal
  4. Ambruticin

Ambruticin (W7783) 是一种口服有效的抗真菌抗生素。Ambruticin 是一类抗生素，可以从 Polyangium cellulosum var. fulvum 菌株中分离出来。Ambruticin 是一种环丙基多烯吡喃酸，具有抗真菌活性。

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Ambruticin Chemical Structure

Ambruticin Chemical Structure

CAS No. : 58857-02-6

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Ambruticin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ambruticin (W7783) is an orally active and potent antifungal antibiotic. Ambruticin represents a class of antibiotics, that can be isolated from a strain of Polyangium cellulosum var. fulvum, a bacterium belonging to the class Myxobacteriales. Ambruticin is a cyclopropyl-polyene-pyran acid and is active against fungi[1].

体外研究
(In Vitro)

Ambruticin 对酵母菌和丝状期的荚膜梭菌和皮炎芽孢杆菌具有高度活性，MIC 范围为 0.049 至 0.39 μg/mL，活性顺序与两性霉素 B (HY-B0221) 相似[2]。
Ambruticin 针对 M.fulvum 的 MIC 为 1.56 μg/mL，灰黄霉素 (HY-17583) 针对 M.fulvum 的MIC 为 3.12 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ambruticin 相关抗体:
体内研究
(In Vivo)

Ambruticin钠盐对小鼠的急性LD50值为：静脉注射315 mg/kg，口服>1000 mg/kg[1]。
Ambruticin 在小鼠体内通过口服途径迅速吸收。Ambruticin (75 mg/kg，灌胃)产生的血清峰值浓度为 46 μg/mL，血清半衰期为 3.1 小时[2]。
Ambruticin (40 mg/kg, 口服，每天两次，共10天) 对感染严重 T. mentagrophytes 的豚鼠显示出保护活性[2]。
Ambruticin 对急性感染严重白色念珠菌的小鼠显示出保护活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pigs (infected with a strain of T. mentagrophytes)[2]
Dosage: 40 mg/kg
Administration: Oral, starting on day 3 postinfection, twice daily for a total of 10 days
Result: On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed.
分子量

474.63

Formula

C28H42O6
CAS 号
结构分类
初始来源

Polyangium cellulosum fulvum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ambruticin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambruticin58857-02-6W7783W 7783W-7783AntibioticFungalAntifungalantibioticcyclopropyl-polyene-pyran acidInhibitorinhibitorinhibit

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目录号：
HY-121050
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