2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. Aplyronine A

Aplyronine A 是一种特异性肌动蛋白解聚剂。 Aplyronine A 具有抗肿瘤和凋亡作用。 Aplyronine A 可用于癌症、肌肉收缩、细胞运动和细胞分裂的研究。

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Aplyronine A Chemical Structure

Aplyronine A Chemical Structure

CAS No. : 151923-84-1

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Aplyronine A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].

IC50 & Target

IC50: 0.01 nM (HeLa S3 cells)[1].
EC50: 1.3 μM (F-actin)[1]
体外研究
(In Vitro)

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC50 value of 0.01 nM[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aplyronine A 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 0-1 μM
Incubation Time: 0-2 h
Result: Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.
体内研究
(In Vivo)

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1076.44

Formula

C59H101N3O14
CAS 号
结构分类
初始来源

Aplysia kurodai
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aplyronine A 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aplyronine A151923-84-1AutophagyApoptosisspecificactin-depolymerizingantitumorapoptosiscancermuscle contractioncell motilitycell divisionHeLa S3 cellsInhibitorinhibitorinhibit

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