2. Anti-infection
  3. Bacterial HCV SARS-CoV
  4. Astodrimer

Astodrimer  (Synonyms: SPL7013 free base)

目录号: HY-P3626
产品使用指南

摩尔计算器

Astodrimer (SPL7013 free base) 是一种大的 (3-4 nm, ~ 16.5 kDa)、带负电荷、高度分支化的树枝状大分子，是一种有效的杀病毒剂。Astodrimer 对包括 SARS-CoV-2、HIV-1、HSV-1、HSV-2、HPV 在内的广谱病毒具有抗病毒和杀病毒活性。Astodrimer 还具有抗菌特性。

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Custom Peptide Synthesis

Astodrimer Chemical Structure

Astodrimer Chemical Structure

CAS No. : 1379746-42-5

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Customer Review

Astodrimer 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties[1][2][3].

体外研究
(In Vitro)

Astodrimer (0-10 mg/mL; 4 days) inhibits SARS-CoV-2 (hCoV-19/Australia/VIC01/2020) replication against SARS-CoV-2 (hCoV-19/Australia/VIC01/2020) infection of Vero E6 cells[1].
Astodrimer inhibits the 2019-nCoV/USA-WA1/2020 strain with EC50 values of 0.019–0.032 mg/mL and 0.030–0.037 mg/mL for infectious virus in Vero E6 cell and Calu-3 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Astodrimer 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Vero E6 cells
Concentration: 0-10 mg/mL(1 h prior to infection, or 1 h post-infection with SARS-CoV-2)
Incubation Time: 4 days
Result: Inhibited viral replication when added either 1 h prior to infection, or 1 h post-infection with SARS-CoV-2 in a dose dependent manner.
体内研究
(In Vivo)

Astodrimer (3%, 8 times daily for 4 days then 4 times daily for 6 days) is non-toxic to rabbit eyes and has anti-adenoviral activity in NZW rabbits[2].
Astodrimer (1%, intranasal administration; once daily for 5 days) reduces the severity of SARS-CoV-2 replication and pathogenesis in the highly susceptible K18-hACE2 mouse model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Two- to three-pound female NZW rabbits (both eyes with HAdV5 following corneal scarification)[2].
Dosage: 3% SPL7013
Administration: 8 times daily for 4 days then 4 times daily for 6 days
Result: Inactivated the virus, and the resulting reduction in the exposure to the virus in vivo limits SARS-CoV-2 infection, resulting in significantly lower viral loads and infectious virus in the lung, trachea, brain and liver of K18-hACE2 mic, and significantly lower pro-inflammatory cytokine production.
Animal Model: Six-to-eight-week-old K18-hACE2 mice[3]
Dosage: 1% astodrimer sodium nasal spray
Administration: Intranasal administration; 25 µL/nostril; once daily on Days 1-6.
Result: Significantly reduced the severity of SARS-CoV-2 replication and pathogenesis in the highly susceptible K18-hACE2 mouse model.
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Astodrimer 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astodrimer1379746-42-5SPL7013SPL 7013SPL-7013BacterialHCVSARS-CoVHepatitis C virusSARS coronavirusAntiviralvirucidalSARS-CoV-2intranasal administrationVero E6 cellsCalu-3 cellsantibacterialInhibitorinhibitorinhibit

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