1. GPCR/G Protein
  2. GNRH Receptor
  3. BAY-784

BAY-784 

目录号: HY-133080
产品使用指南

BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针,对人和大鼠 GnRH-RIC50 分别为 21 和 24 nM。

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BAY-784 Chemical Structure

BAY-784 Chemical Structure

CAS No. : 1631164-24-3

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Description

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].

IC50 & Target

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]

In Vivo

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1].

Animal Model: OVX rats[1]
Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration: Single p.o.
Result: ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
Molecular Weight

672.11

Formula

C₂₉H₂₆ClF₄N₃O₅S₂

CAS No.

1631164-24-3

SMILES

O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BAY-784BAY784BAY 784GNRH ReceptorGonadotropin releasing hormone receptorGNRHRGnRH-RprobeInhibitorinhibitorinhibit

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产品名称:
BAY-784
目录号:
HY-133080
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