2. Epigenetics
  3. Histone Acetyltransferase Epigenetic Reader Domain
  4. CBP/p300-IN-20

CBP/p300-IN-20 是一种有效和选择性的 p300/CBP 抑制剂，对 p300 的 pIC50 为 10.1。CBP/p300-IN-20 可用于癌症相关研究。

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CBP/p300-IN-20 Chemical Structure

CBP/p300-IN-20 Chemical Structure

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规格 价格 是否有货
1 mg ￥2240
询问价格 & 货期
5 mg ￥5040
询问价格 & 货期
10 mg ￥8100
询问价格 & 货期

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Customer Review

CBP/p300-IN-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer[1].

IC50 & Target[1]

CBP/p300

10.1 (pIC50)

体外研究
(In Vitro)

CBP/p300-IN-20 (compound 28) decreases Myc protein in cell-based cMyc HTRF assay, with a pEC50 of 8.5[1].
CBP/p300-IN-20 (1 μM) shows 97% inhibition for p300 and 80% inhibition for CPB[1].
CBP/p300-IN-20 (0.3-1000 nM; 2 h) decreases H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3 in COLO 320HSR cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBP/p300-IN-20 相关抗体:

Western Blot Analysis[1]

Cell Line: COLO 320HSR cells
Concentration: 0.3, 1, 3, 10, 30, 100, 300, 1000 nM
Incubation Time: 2 hours
Result: Caused a rapid concentration-dependent decrease in H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3.
体内研究
(In Vivo)

CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits Cmax (210 ng/mL), AUC0→∞ (102 h•ng/mL), CL (95 mL/min/kg), and T1/2 (0.3 h) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

477.87

Formula

C22H19ClF3N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CBP/p300-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP/p300-IN-20Histone AcetyltransferaseEpigenetic Reader DomainHATsHATH3K18H3K27acetylationH3K9total H3Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151812
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