2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. CDK Apoptosis c-Myc Caspase PARP
  4. CDK9-IN-42

CDK9-IN-42 是一种强效且具有选择性的 CDK9 抑制剂，其 IC50 值为 3.8 nM。CDK9-IN-42 可通过下调 Myc-1 和 c-Myc 来抑制癌细胞生长并诱导细胞凋亡 (apoptosis)。CDK9-IN-42 可用于癌症研究，如乳腺癌和肺癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK9-IN-42

CDK9-IN-42 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK9-IN-42 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK9-IN-42 is a potent and selective CDK9 inhibitor with an IC50of 3.8 nM. CDK9-IN-42 can inhibit the growth of cancer cells and induce apoptosis by downregulating Myc-1 and c-Myc. CDK9-IN-42 can be used for the research of cancer, such as breast and lungcancer[1].

IC50 & Target[1]

CDK9

3.8 nM (IC50)

Caspase 3

 

体外研究
(In Vitro)

CDK9-IN-42 (Compound L18) (72 h) 可抑制多种血液肿瘤细胞的增殖，对 MV4-11、MOLM-13、THP-1、KG-1 和 HL-60 细胞的 IC50 值分别为 0.049 μM、0.071 μM、0.062 μM、0.093 μM 和 0.175 μM[1]。
CDK9-IN-42 (72 h) 可抑制多种实体肿瘤细胞的增殖，对 HepG2、MCF-7、22RV1 和 A549 细胞的 IC50 值分别为 0.045 μM、0.166 μM、0.247 μM 和 0.225 μM[1]。
CDK9-IN-42 (0.1-1 μM, 72 h) 对正常人支气管上皮细胞的细胞毒性较低，对 BEAS-2B 细胞的 IC50 值为 0.402 μM[1]。
CDK9-IN-42 对 CDK9 表现出优异的选择性，对 CDK 家族成员 CDK1、CDK4、CDK6 和 CDK7 的 IC50 均大于 1 μM[1]。
CDK9-IN-42 (0.1-0.5 μM, 12 h) 可下调 MV4-11 细胞中 p-RNAPII-ser2、Mcl-1、c-Myc、CDK9 和细胞周期蛋白 T1 的蛋白水平[1]。
CDK9-IN-42 (0.5-1 μM, 12 h) 可诱导 MV4-11 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK9-IN-42 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.1, 0.25, 0.5, 1 and 2 μM
Incubation Time: 2, 4, 8, 12 and 24 h
Result: Decreased levels of p-RNAPII-ser2, Mcl-1, c-Myc, CDK9 and Cyclin T1 protein.

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.5 and 1 μM
Incubation Time: 12 h
Result: Increased apoptosis rates.
Downregulated PARP and Caspase-3 proteins.
Upregulated Cleaved-PARP and Cleaved-Caspase-3.
体内研究
(In Vivo)

CDK9-IN-42 (Compound L18) (15-50 mg/kg，静脉注射，单剂量) 在 ICR 小鼠中未出现死亡或显著体重减轻的情况[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 15, 30 and 50 mg/kg
Administration: Intravenously, Subcutaneous
Result: Showed no death or significant weight loss.
分子量

498.55

Formula

C22H19FN6O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK9-IN-42 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-42CDKApoptosisc-MycCaspasePARPCyclin dependent kinaseMycpoly ADP ribose polymeraseCDK9Myc-1MV4-11MOLM-13HepG2MCF-7Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK9-IN-42
目录号：
HY-178039
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z