2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. CST651

CST651  (Synonyms: PROTAC CDK4/6 degrader 34)

目录号: HY-134303
产品使用指南 技术支持

CST651 (PROTAC CDK4/6 degrader 34) 是一种选择性的细胞周期蛋白依赖性激酶 CDK4/6 PROTAC降解剂。CST651 能够降解 MM.1S 细胞中的 CDK4 和 CDK6，其 DC50 值分别为 20 nM 和 5.1 nM。CST651 可以抑制癌细胞的增殖和迁移。CST651 可用于癌症研究，如急性淋巴细胞白血病。(结构：粉色：CDK4/6 配体 (HY-50767)；蓝色：VHL 连接酶配体 (HY-125905)；黑色：连接子 (HY-W017440))

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CST651

CST651 Chemical Structure

CAS No. : 2489241-16-7

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CST651 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC50 values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia[1]. (Structure Note: Pink: CDK4/6 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440))

IC50 & Target[1]

CDK6

5.1 nM (DC50, In MM.1S cells)

CDK4

20 nM (DC50, In MM.1S cells)

VHL

 

分子量

1094.30

Formula

C56H72FN11O9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CST651 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CST6512489241-16-7PROTAC CDK4/6 degrader 34CST 651CST-651PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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