2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. D-threo-PDMP

D-threo-PDMP 是一种有效得葡萄糖神经酰胺合成酶 (GCS) 抑制剂 , 可以通过抑制糖基化来减少细胞表面糖鞘脂， 可减少轴突丛的总长度和轴突分支点的数量，抑制神经突的生长。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-threo-PDMP Chemical Structure

D-threo-PDMP Chemical Structure

CAS No. : 109836-82-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

D-threo-PDMP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth[1][2].

体外研究
(In Vitro)

D-threo-PDMP 预处理肝细胞可消除 TNF-α（280 ng/mL）对糖磷脂水平的刺激并增强神经酰胺的产生[1]。
D-threo-PDMP（20μM，48小时）明显刺激系膜肾小球系膜细胞（GMC）的增殖，这些增殖被外源神经节苷脂混合物（0.1-0.2 mg/mL）或 GM3（20-100 μM）以剂量依赖的方式明显减弱。它还诱发了神经节苷脂表达的明显减少[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-threo-PDMP 相关抗体:
分子量

390.56

Formula

C23H38N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-threo-PDMP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-threo-PDMP109836-82-0Glucosylceramide Synthase (GCS)GCSglycosylationglycosphingolipidsneurite growthInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
D-threo-PDMP
目录号：
HY-116392E
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z