1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
    NO Synthase
  3. Dimaprit dihydrochloride

Dimaprit dihydrochloride 

目录号: HY-B1478
产品使用指南

Dimaprit dihydrochloride 是一种选择性的组胺 H2 受体激动剂,它还抑制 nNOSIC50 值为 49 μM。Dimaprit dihydrochloride 可刺激胃酸的分泌。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Dimaprit dihydrochloride Chemical Structure

Dimaprit dihydrochloride Chemical Structure

CAS No. : 23256-33-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].

IC50 & Target[1][2]

H2 Receptor

 

nNOS

49 μM (IC50)

In Vitro

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors[1].
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM[2].

In Vivo

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1].

Molecular Weight

234.19

Formula

C₆H₁₇Cl₂N₃S

CAS No.

23256-33-9

SMILES

NC(SCCCN(C)C)=N.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DimapritHistamine ReceptorNO SynthaseNitric oxide synthasesNOShistamineH2receptornNOSgastricacidInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Dimaprit dihydrochloride
目录号:
HY-B1478
需求量: