1. Anti-infection Cell Cycle/DNA Damage
  2. Bacterial Antibiotic DNA/RNA Synthesis
  3. Erythromycin thiocyanate

Erythromycin thiocyanate  (Synonyms: 红霉素硫氰酸盐)

目录号: HY-B0220D
产品使用指南

Erythromycin thiocyanate 是由放线菌产生的大环内酯类抗生素 (antibiotic),具有广泛的抗菌活性。Erythromycin thiocyanate 通过结合细菌的 50S 核糖体亚基而起作用,并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成,而不会影响核酸的合成。Erythromycin thiocyanate 在不同领域的研究中显示出抗肿瘤特性和保护神经的作用。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Erythromycin stearate 通常具有更好的水溶性和稳定性。

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Erythromycin thiocyanate Chemical Structure

Erythromycin thiocyanate Chemical Structure

CAS No. : 7704-67-8

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1 g ¥250
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5 g ¥550
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Erythromycin thiocyanate 的其他形式现货产品:

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Other Forms of Erythromycin thiocyanate:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].

IC50 & Target

Macrolide

 

体外研究
(In Vitro)

Erythromycin thiocyanate inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively[1].
Erythromycin thiocyanate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[4]

Cell Line: Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration: 10, 100 μM
Incubation Time: 24, 72 hours
Result: Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
体内研究
(In Vivo)

Erythromycin thiocyanate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice[3].
Erythromycin thiocyanate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg[3].
Erythromycin thiocyanate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ddY mice (6-week-old) with EAC cells or CDF mice (6-week-old) with P388 cells[3]
Dosage: 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration: Gastric intubation; 30-120 days
Result: Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
Animal Model: Male Sprague-Dawley rats (8-week-old, 250-300 g)[4]
Dosage: 50 mg/kg
Administration: Subcutaneous single injection
Result: Reduced infarct volume and edema volume, improved neurological deficit.
Clinical Trial
分子量

793.02

Formula

C38H68N2O13S

CAS 号
性状

固体

颜色

White to off-white

中文名称

红霉素硫氰酸盐

结构分类
初始来源

Streptomyces erythreHs

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (126.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2610 mL 6.3050 mL 12.6100 mL
5 mM 0.2522 mL 1.2610 mL 2.5220 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2610 mL 6.3050 mL 12.6100 mL 31.5251 mL
5 mM 0.2522 mL 1.2610 mL 2.5220 mL 6.3050 mL
10 mM 0.1261 mL 0.6305 mL 1.2610 mL 3.1525 mL
15 mM 0.0841 mL 0.4203 mL 0.8407 mL 2.1017 mL
20 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5763 mL
25 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2610 mL
30 mM 0.0420 mL 0.2102 mL 0.4203 mL 1.0508 mL
40 mM 0.0315 mL 0.1576 mL 0.3153 mL 0.7881 mL
50 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
60 mM 0.0210 mL 0.1051 mL 0.2102 mL 0.5254 mL
80 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3941 mL
100 mM 0.0126 mL 0.0631 mL 0.1261 mL 0.3153 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Erythromycin thiocyanate
目录号:
HY-B0220D
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