2. Apoptosis
  3. Apoptosis
  4. Fusicoccin

Fusicoccin  (Synonyms: Fusicoccin A)

目录号: HY-122815 纯度: 96.20%
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摩尔计算器

Fusicoccin (Fusicoccin A)，一种真菌化脓毒素，14-3-3 蛋白相互作用的稳定剂。Fusicoccin 使 H+-ATPase/14-3-3 复合物在植物中稳定，保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡，并具有抗癌活性。

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Fusicoccin Chemical Structure

Fusicoccin Chemical Structure

CAS No. : 20108-30-9

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Fusicoccin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity[1][2][3][4].

体外研究
(In Vitro)

Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC50=29 mM)[3].
Fusicoccin A activates the plasma membrane H+-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC50 growth inhibitory concentration of fusicoccin A is 92 µM in the U373-MG cells and 83 µM in the Hs683 glioma cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fusicoccin 相关抗体:
分子量

680.82

Formula

C36H56O12
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Fusicoccum amygdali
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 96.20%

COA (185 KB) LCMS (264 KB)

产品使用指南 (1538 KB)
参考文献

Fusicoccin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fusicoccin20108-30-9Fusicoccin AApoptosisATPasestabilizerprotein-proteininteractionsGBMcellscancerInhibitorinhibitorinhibit

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