1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. GBR 12783 dihydrochloride

GBR 12783 dihydrochloride 

目录号: HY-100968 纯度: ≥98.0%
COA 产品使用指南

GBR 12783 dihydrochloride 是一种特异性,有效且选择性的多巴胺摄取抑制剂,可抑制大鼠和小鼠纹状体突触小体对 [3H] 多巴胺 ([3H]dopamine) 的摄取,IC50 分别为 1.8 nM 和 1.2 nM。GBR 12783 dihydrochloride 还可改善大鼠记忆力并增加海马通路乙酰胆碱的释放。

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GBR 12783 dihydrochloride Chemical Structure

GBR 12783 dihydrochloride Chemical Structure

CAS No. : 67469-75-4

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1 mg ¥571
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5 mg ¥1500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2].

体内研究
(In Vivo)

GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (180-200 g)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; for 100 minutes
Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
分子量

485.49

Formula

C28H34Cl2N2O

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

参考文献

GBR 12783 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GBR 12783 dihydrochloride
目录号:
HY-100968
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