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  3. GPI-1046

GPI-1046 

目录号: HY-124619
产品使用指南

GPI-1046 是一种不含抗生素作用的免疫亲和素配体,通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白1 (GLT1) 来减少乙醇摄入。GPI-1046 是 FK506 的类似物,在神经退行性疾病模型中显示出神经保护作用。GPI-1046 易穿过血脑屏障并促进中枢神经系统中多巴胺 (DA) 细胞的再生,这与啮齿动物模型中的功能恢复相关。

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GPI-1046 Chemical Structure

GPI-1046 Chemical Structure

CAS No. : 186452-09-5

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Description

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2].

IC50 & Target[1]

GLT1

 

Molecular Weight

360.45

Formula

C₂₀H₂₈N₂O₄

CAS No.

186452-09-5

SMILES

O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2

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Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
GPI-1046
目录号:
HY-124619
需求量:

GPI-1046

Cat. No.: HY-124619