2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. TCS2002

TCS2002 (Compound 9b) 是一种高选择性、口服有效的 GSK-3β 抑制剂，IC50 为 35 nM。TCS2002 具有良好的药代动力学特征，且可透过血脑屏障。TCS2002 可用于阿尔茨海默病的研究。

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TCS2002 Chemical Structure

TCS2002 Chemical Structure

CAS No. : 1005201-24-0

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规格 价格 是否有货 数量
5 mg ￥3671
3 - 4 周
10 mg ￥5875
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

TCS2002 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease[1].

IC50 & Target[1]

GSK-3

35 nM (IC50)

体内研究
(In Vivo)

TCS2002 (Compound 9b) (1-3 mg/kg;1-24 hours; GS rats andC57BL/6N mice) exhibits good pharmacokinetic profiles and favor able BBB permeability with AUC0-24h value is 734 ng•h/g and Kp value (ratio of brain and plasma) is 1.6[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IGS rats (male, 8 weeks old)[1]
Dosage: 1 and 3mg/kg
Administration: Intravenous injection and oral administration;for 1, 2, 4, 8, 24 hours.
Result: 1.19
comp (S)-9b (S)-9c
VDSS,iv (mL/kg) 1134 1650
CLtotal,iv (mL/min/kg) 27.4 28.4
Cmax,po (ng/mL) 396.9 289.6
AUC0-24 h,po (ng·h/mL) 1380.6 1229.1
MRTpo (h) 2.19 3.03
Fd (%) 72.8 65.5
分子量

338.38

Formula

C18H14N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TCS2002 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCS20021005201-24-0TCS 2002TCS-2002GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3orally bioavailableGSK-3β inhibitorgood pharmacokinetic profileBBB penetrationAlzheimer diseaseInhibitorinhibitorinhibit

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产品名称：
TCS2002
目录号：
HY-10096
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