2. Others Neuronal Signaling
  3. Fluorescent Dye Monoamine Oxidase
  4. HDAC-MB

HDAC-MB 是一种可被 HDAC6 激活的探针，可以通过被 HDAC6 激活来检测并消除神经胶质瘤细胞。HDAC-MB 具由抗转移和抗增殖活性，抑制神经胶质瘤侵袭并且诱导细胞凋亡 (apoptosis)。

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HDAC-MB Chemical Structure

HDAC-MB Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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HDAC-MB 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis[1].

体外研究
(In Vitro)

HDAC-MB (10 μM) 可以被 HDAC6 激活，产生近红外荧光并且对 HDAC6 成像[1]。
HDAC-MB (0-5 μM) 在细胞 HeLab 和 U251 中具有可被 HDAC6 激活的光毒性[1]。
HDAC-MB (5 μM) 通过 MAO A 抑制和 PDT 的协同作用，抑制胶质瘤细胞迁移、侵袭和增殖，诱导胶质瘤细胞凋亡 (apoptosis)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-MB 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa
Concentration: 0-5 μM
Incubation Time: 24 h
Result: Revealed a dose-dependent cytotoxicity.

Cell Migration Assay [1]

Cell Line: U251 cells
Concentration: 1 μM
Incubation Time: 24 h
Result: Reduced the cell migration by 40% with no irradiation, reduced the cell migration by 70% with light irradiation.

Apoptosis Analysis[1]

Cell Line: U251 cells
Concentration: 15 μM
Incubation Time: 24 h
Result: Induced apoptosis upon NIR light irradiation.
分子量

590.73

Formula

C32H38N4O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-MB 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-MBFluorescent DyeMonoamine OxidaseMAOglioblastoma multiformeHeLa cellsU251 cellsInhibitorinhibitorinhibit

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