2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC3-IN-5

HDAC3-IN-5 (9c) 是选择性的 HDAC3 抑制剂，其对 HDAC3、HDAC2 和 HDAC1 的 IC50 值分别为 4.2 nM、1629 nM 和 298.2 nM。HDAC3-IN-5 (9c) 在体外有效诱导 MV4-11 细胞凋亡并降低抗凋亡蛋白的表达，HDAC3 选择性抑制剂的开发可能作为逆转 Venetoclax 耐药的潜在先导化合物。

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HDAC3-IN-5

HDAC3-IN-5 Chemical Structure

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HDAC3-IN-5 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC3-IN-5 (9c) is a HDAC3 selective inhibitor, with IC50 values of 4.2 nM, 1629 nM and 298.2 nM for HDAC3, HDAC2, HDAC1, respectively. HDAC3-IN-5 (9c) can effectively induce apoptosisin MV4-11 cells in vitro and reduce the expression of anti-apoptotic proteins, the development of HDAC3 selective inhibitors may serve as a potential lead compound to reverse Venetoclax resistance[1].

IC50 & Target[1]

HDAC3

4.2 nM (IC50)

HDAC1

298.2 nM (IC50)

HDAC2

1629 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
JeKo-1 IC50
484 nM
Compound: 9c
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
K562 IC50
383 nM
Compound: 9c
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
MV4-11 IC50
315 nM
Compound: 9c
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
分子量

446.63

Formula

C28H38N4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC3-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3-IN-5HDACApoptosisHistone deacetylasesMV4-11 Venetoclaxanti-apoptoticInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162769
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