2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-18

HDAC6-IN-18 (Compound 4) 是第一个不可逆的 HDAC6 亚型选择性抑制剂，具有有效的抗多发性骨髓瘤活性。 HDAC6-IN-18 在 RPMI8266、U266 和 MM.1S 细胞中具有 HDAC6 抑制活性，IC50 值分别为 0.17、0.7 和 0.42 μM[1 ]。

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HDAC6-IN-18

HDAC6-IN-18 Chemical Structure

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HDAC6-IN-18 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-18 (Compound 4) is a first irreversible HDAC6 isoform selective inhibitor with potent anti-multiple myeloma activity. HDAC6-IN-18 has HDAC6 inhibitory activity in RPMI8266, U266 and MM.1S cells with IC50 values of 0.17, 0.7 and 0.42 μM, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
L02 IC50
8.2 μM
Compound: 4
Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 37463038]
MM1.S IC50
0.42 μM
Compound: 4
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 37463038]
RPMI-8226 IC50
0.17 μM
Compound: 4
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 37463038]
U-266 IC50
0.7 μM
Compound: 4
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 37463038]
分子量

391.36

Formula

C16H13N3O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-18HDACHistone deacetylasesirreversibleHDAC6RPMI8266U266MM.1Santi-multiple myelomaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-155671
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