HDAC6-IN-19

目录号: HY-149497: Data Sheet 产品使用指南
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HDAC6-IN-19 (Compound 14g) 是一种 HDAC6 抑制剂 (IC₅₀: 2.68 nM)。HDAC6-IN-19 还抑制 HDAC1、HDAC2 和 HDAC3，IC₅₀ 分别为 61.6 nM、98.7 nM 和 103 nM。HDAC6-IN-19 有效抑制多种癌细胞增殖，包括白血病、结肠癌、黑色素瘤和乳腺癌细胞系。

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HDAC6-IN-19 Chemical Structure

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HDAC6-IN-19 相关产品

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

生物活性
纯度 & 产品资料
参考文献

生物活性

HDAC6-IN-19 (Compound 14g) is a HDAC6 inhibitor (IC₅₀: 2.68 nM). HDAC6-IN-19 also inhibits HDAC1, HDAC2 and HDAC3 with IC₅₀s of 61.6 nM, 98.7 nM and 103 nM. HDAC6-IN-19 potently inhibits multiple cancer cell proliferation, including leukemia, colon cancer, melanoma, and breast cancer cell lines^[1].

IC₅₀ & Target

2.68 nM, 61.6 nM, 98.7 nM and 103 nM (HDAC6, HDAC1, HDAC2 and HDAC3)^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	3.71 μM Compound: 14g	Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
A498	GI₅₀	2.06 μM Compound: 14g	Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
A549	GI₅₀	3.97 μM Compound: 14g	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
ACHN	GI₅₀	3.05 μM Compound: 14g	Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
BT-549	GI₅₀	4.93 μM Compound: 14g	Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
CAKI-1	GI₅₀	2.33 μM Compound: 14g	Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
CCRF-CEM	GI₅₀	0.617 μM Compound: 14g	Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
COLO 205	GI₅₀	0.719 μM Compound: 14g	Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
DU-145	GI₅₀	1.08 μM Compound: 14g	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
EKVX	GI₅₀	2.65 μM Compound: 14g	Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HCC 2998	GI₅₀	0.605 μM Compound: 14g	Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HCT-116	GI₅₀	0.609 μM Compound: 14g	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HCT-15	GI₅₀	4.26 μM Compound: 14g	Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HL-60(TB)	GI₅₀	0.706 μM Compound: 14g	Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HOP-62	GI₅₀	1.27 μM Compound: 14g	Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HOP-92	GI₅₀	0.93 μM Compound: 14g	Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
HT-29	GI₅₀	0.838 μM Compound: 14g	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
Hs-578T	GI₅₀	1.01 μM Compound: 14g	Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
IGROV-1	GI₅₀	1.2 μM Compound: 14g	Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
K562	GI₅₀	0.72 μM Compound: 14g	Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
KM12	GI₅₀	2.36 μM Compound: 14g	Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
LOX IMVI	GI₅₀	1.09 μM Compound: 14g	Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
M14	GI₅₀	2.2 μM Compound: 14g	Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
MCF7	GI₅₀	0.874 μM Compound: 14g	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
MDA-MB-231	GI₅₀	0.887 μM Compound: 14g	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
MDA-MB-435	GI₅₀	0.959 μM Compound: 14g	Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
MDA-MB-468	GI₅₀	0.38 μM Compound: 14g	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
MOLT-4	GI₅₀	0.563 μM Compound: 14g	Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
Malme-3M	GI₅₀	0.41 μM Compound: 14g	Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI-H226	GI₅₀	2.27 μM Compound: 14g	Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI-H23	GI₅₀	1.33 μM Compound: 14g	Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI-H322M	GI₅₀	1.62 μM Compound: 14g	Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI-H460	GI₅₀	1.02 μM Compound: 14g	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI-H522	GI₅₀	0.584 μM Compound: 14g	Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
NCI/ADR-RES	GI₅₀	3.35 μM Compound: 14g	Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
OVCAR-3	GI₅₀	1.23 μM Compound: 14g	Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
OVCAR-4	GI₅₀	3.73 μM Compound: 14g	Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
OVCAR-5	GI₅₀	0.456 μM Compound: 14g	Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
OVCAR-8	GI₅₀	0.942 μM Compound: 14g	Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
PC-3	GI₅₀	1.76 μM Compound: 14g	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
RPMI-8226	GI₅₀	0.564 μM Compound: 14g	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
RPMI-8226	IC₅₀	0.62 μM Compound: 14g	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
RXF 393	GI₅₀	0.455 μM Compound: 14g	Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SF-268	GI₅₀	2.92 μM Compound: 14g	Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SF-295	GI₅₀	1.81 μM Compound: 14g	Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SF-539	GI₅₀	1.14 μM Compound: 14g	Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SK-MEL-2	GI₅₀	2.77 μM Compound: 14g	Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SK-MEL-28	GI₅₀	0.878 μM Compound: 14g	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SK-MEL-5	GI₅₀	0.721 μM Compound: 14g	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SK-OV-3	GI₅₀	2.01 μM Compound: 14g	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SN12C	GI₅₀	2.41 μM Compound: 14g	Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SNB-19	GI₅₀	2.26 μM Compound: 14g	Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SNB-75	GI₅₀	2.26 μM Compound: 14g	Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SR	GI₅₀	1.15 μM Compound: 14g	Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
SW-620	GI₅₀	0.687 μM Compound: 14g	Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
T47D	GI₅₀	0.6 μM Compound: 14g	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
TK-10	GI₅₀	1.51 μM Compound: 14g	Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
U-251	GI₅₀	1.21 μM Compound: 14g	Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
UACC-257	GI₅₀	1.23 μM Compound: 14g	Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
UACC-62	GI₅₀	0.538 μM Compound: 14g	Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]
UO-31	GI₅₀	2.64 μM Compound: 14g	Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay	[PMID: 37660484]

分子量

474.94

Formula

C₂₆H₂₃ClN₄O₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Chen X, et al. Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity. Eur J Med Chem. 2023 Nov 15;260:115776. [Content Brief]

HDAC6-IN-19 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-19HDACHistone deacetylasescancerleukemiacolon cancermelanomaand breast cancerInhibitorinhibitorinhibit

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HDAC6-IN-19

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HDAC6-IN-19 相关分类

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HDAC6-IN-19

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HDAC6-IN-19 相关产品

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•同靶点蛋白产品:

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生物活性

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HDAC6-IN-19 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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