Iodophenpropit dihydrobromide 

Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [¹²⁵I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (K_D 0.32 nM)^[1].

Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor^[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC₅₀ of 1.57±0.3 μM^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

576.13

C₁₅H₂₁Br₂IN₄S

145196-87-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [¹²⁵I]Iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur J Pharmacol. 1992 Jul 7;217(2-3):203-5.  [Content Brief]

  [2]. Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21.  [Content Brief]

  [3]. Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8.  [Content Brief]

  [4]. Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.