2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. JNJ10191584

JNJ10191584  (Synonyms: VUF6002)

目录号: HY-123532
产品使用指南

摩尔计算器

JNJ10191584 (VUF6002) 是具有口服活性的、选择性的 histamine H4 受体 拮抗剂，Ki 值为 26 nM。JNJ10191584 对 H4 受体的选择性是 H3 受体的 540 倍，对 H3 受体的 Ki 值为 14.1 μM。JNJ10191584 抑制嗜酸性粒细胞和肥大细胞的趋化作用，IC50 值分别为 530 nM 和 138 nM。

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JNJ10191584 Chemical Structure

JNJ10191584 Chemical Structure

CAS No. : 73903-17-0

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JNJ10191584 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].

IC50 & Target

Human H4 Receptor

26 nM (Ki)

human H3 receptor

14.1 μM (Ki)

体外研究
(In Vitro)

JNJ10191584 shows binding affinity of 26 nM and 14.1 μM to H4 and H3 receptor, respectively[1].
JNJ10191584 (3 h) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ10191584 相关抗体:
体内研究
(In Vivo)

JNJ10191584 (10 μg/μL; intra locus coeruleus (LC) administration; once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice[1].
JNJ10191584 (10 μg/μL; intra LC administration; once) prevents the anti-allodynic effect of VUF 8430 in SNI mice[1].
JNJ10191584 (6 μg/mouse; intrathecal administration; pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

278.74

Formula

C13H15ClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ10191584 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ1019158473903-17-0VUF6002JNJ 10191584JNJ-10191584VUF 6002VUF-6002Histamine Receptorbenzimidazolechemotaxiseosinophilsmast cellsselectiveoralanti-allodyniclocus coeruleusVUF 8430Inhibitorinhibitorinhibit

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