2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis Protein Tyrosine Kinase/RTK MAPK/ERK Pathway JAK/STAT Signaling Stem Cell/Wnt
  3. HSP Apoptosis Bcr-Abl p38 MAPK CDK STAT
  4. KW-2478 hydrochloride

KW-2478 (hydrochloride) 是一种 HSP90 抑制剂 (IC50 = 3.8 nM)。KW-2478 (hydrochloride) 抑制慢性粒细胞白血病细胞和肝癌细胞的生长并诱导细胞凋亡 (apoptosis)。KW-2478 (hydrochloride) 削弱 BCR/ABL 和 MAPK 信号通路，导致 p27 和 p21 表达增加，细胞周期蛋白 B1 表达减少。KW-2478 (hydrochloride) 下调了 STAT3 的表达。KW-2478 (hydrochloride) 可用于慢性粒细胞白血病和肝癌等癌症的研究。

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KW-2478 hydrochloride

KW-2478 hydrochloride Chemical Structure

CAS No. : 819812-18-5

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KW-2478 hydrochloride 的其他形式现货产品:

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KW-2478 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 Bcr-Abl 亚型特异性产品:

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Abl Bcr-Abl

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KW-2478 (hydrochloride) is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 (hydrochloride) inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 (hydrochloride) weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 (hydrochloride) downregulates STAT3 expression. KW-2478 (hydrochloride) may be used in research on cancers such as CML and liver cancer[1][2].

分子量

611.12

Formula

C30H43ClN2O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KW-2478 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KW-2478819812-18-5KW2478KW 2478HSPApoptosisBcr-Ablp38 MAPKCDKSTATHeat shock proteinsCyclin dependent kinaseInhibitorinhibitorinhibit

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