1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Lodenafil

Lodenafil (Synonyms: Hydroxyhomosildenafil)

目录号: HY-123210 纯度: 99.73%
产品使用指南

Lodenafil 是有效的磷酸二酯酶5型 (PDE5) 抑制剂,可用于治疗勃起功能障碍。

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Lodenafil Chemical Structure

Lodenafil Chemical Structure

CAS No. : 139755-85-4

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1665 In-stock
5 mg ¥1500 In-stock
10 mg ¥2500 In-stock
50 mg ¥8500 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED)[1].

IC50 & Target[1]

PDE5

 

Clinical Trial
Molecular Weight

504.60

Formula

C₂₃H₃₂N₆O₅S

CAS No.

139755-85-4

SMILES

O=C1C2=C(NC(C3=CC(S(=O)(N4CCN(CC4)CCO)=O)=CC=C3OCC)=N1)C(CCC)=NN2C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (495.44 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9818 mL 9.9088 mL 19.8177 mL
5 mM 0.3964 mL 1.9818 mL 3.9635 mL
10 mM 0.1982 mL 0.9909 mL 1.9818 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References

Purity: 99.73%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Lodenafil
目录号:
HY-123210
需求量:

Lodenafil

Cat. No.: HY-123210