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    Neuronal Signaling
  2. mAChR
  3. PQCA

PQCA 

目录号: HY-118342
产品使用指南

PQCA 是一种高度选择性且有效的毒蕈碱 M1 受体阳性变构调节剂。PQCA 在恒河猴和人 M1 受体上的 EC50 值分别为 49 nM 和 135 nM,并且对其他毒蕈碱受体无活性。PQCA 可改善大鼠,食蟹猕猴和恒河猴的认知能力和脑血流量,并具有减少与阿尔茨海默氏病相关的认知缺陷的潜力。

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PQCA Chemical Structure

PQCA Chemical Structure

CAS No. : 1144504-35-7

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Description

PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].

IC50 & Target

EC50: 49 nM (Rhesus M1 receptor) and 135 nM (Human M1 receptor)[1]

In Vivo

PQCA (3-30 mg/kg; Oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks[1].

Animal Model: Ten single- or pair-housed male rhesus monkeys (6-10 years old; 5.2-10.5 kg) with scopolamine[1]
Dosage: 3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration: Oral administration
Result: Attenuated the scopolamine deficits in paired-associates learning (PAL) and the continuous-performance task (CPT).
Molecular Weight

388.42

Formula

C₂₂H₂₀N₄O₃

CAS No.

1144504-35-7

SMILES

O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PQCAmAChRMuscarinic acetylcholine receptorMemorytranslatableM1scopolamineAlzheimer'sdiseasecognitivecerebralbloodflowInhibitorinhibitorinhibit

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产品名称:
PQCA
目录号:
HY-118342
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