2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease Stem Cell/Wnt Membrane Transporter/Ion Channel MAPK/ERK Pathway NF-κB Immunology/Inflammation
  3. AMPK PEPCK GSK-3 GLUT Akt p38 MAPK Reactive Oxygen Species (ROS)
  4. Pterosin A

Pterosin A  (Synonyms: (2S)-Pterosin A)

目录号: HY-N7912 纯度: 94.07%
COA 产品使用指南 技术支持

Pterosin A ((2S)-Pterosin A) 是一种倍半萜类化合物。Pterosin A 是一种具有口服活性的 AMP 活化蛋白激酶 (AMPK) 激活剂，具有抗糖尿病作用。Pterosin A 能促进葡萄糖摄取，增加血清胰岛素，改善高血糖和葡萄糖不耐受。Pterosin A 可以防止胰岛素分泌细胞死亡并减少活性氧 (ROS) 的产生。Pterosin A 可用于代谢疾病的研究，如糖尿病。

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Pterosin A

Pterosin A Chemical Structure

CAS No. : 35910-16-8

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1 mg ￥4800
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Pterosin A 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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GSK-3 GSK-3α GSK-3β

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GLUT1 GLUT2 GLUT3 GLUT4

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Akt Akt1 Akt2 Akt3

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes[1][2].

IC50 & Target[1]

GLUT4

 

p-GSK-3

 

体外研究
(In Vitro)

Pterosin A (50 μg/mL, 0.5-4 h) 可增强肌肉细胞中的葡萄糖摄取和 AMPK 磷酸化[1]。
Pterosin A (50-150 μg/mL, 0.5-4 h) 可抑制肝细胞中 PEPCK 的表达，触发 AMPK、ACC 和 GSK-3 的磷酸化，降低糖原合酶的磷酸化，并增加细胞内糖原水平[1]。
Pterosin A (10-100 μM, 18 h) 可抑制 H2O2 诱导的 RINm5fβ 细胞中活性氧的产生[2]。
Pterosin A (10-100 μM, 18 h) 可减少脂毒性诱导的 RINm5fβ 细胞死亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pterosin A 相关抗体:

Western Blot Analysis[1]

Cell Line: Liver cells
Concentration: 50 and 150 μg/mL
Incubation Time: 0.5, 1, 2 and 4 h
Result: Increased p-AMPK and P-ACC and p-GSK3-α/β levels.
体内研究
(In Vivo)

Pterosin A (10-100 mg/kg，口服，每日一次，连续 4 周) 可改善糖尿病小鼠的高血糖和葡萄糖不耐受症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753), high-fat diet-fed and db/db diabetic mice models[1]
Dosage: 10, 30 and 100 mg/kg
Administration: Orally administration, daily for 4 weeks
Result: Reversed the increased serum insulin and insulin resistance in dexamethasone-IR mice.
Reversed the reduced muscle GLUT-4 translocation and the increased liver phosphoenolpyruvate carboxyl kinase (PEPCK) expression.
Reversed the decreased phosphorylations of AMP-activated protein kinase (AMPK) and Akt in muscles.
Reversed increased p38 phosphorylation in livers.
分子量

248.32

Formula

C15H20O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Pterosin A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pterosin A35910-16-8(2S)-Pterosin AAMPKPEPCKGSK-3GLUTAktp38 MAPKReactive Oxygen Species (ROS)AMP-activated protein kinasePhosphoenolpyruvate CarboxykinaseGlycogen synthase kinase-3Glycogen synthase kinase 3Glucose transporter PKBProtein kinase BPteridium aquilinumAnti-diabeticGlucoseInsulinHyperglycemiaDiabetesInhibitorinhibitorinhibit

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