2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. Ruscogenin

Ruscogenin  (Synonyms: 鲁斯可皂苷元)

目录号: HY-N0496 纯度: 99.59%
COA 产品使用指南

摩尔计算器

Ruscogenin 是从 Ophiopogon japonicus 提取的一种重要甾体皂苷元，通过抑制 TXNIP/NLRP3 炎症体激活和 MAPK 途径减轻脑缺血诱导的血脑屏障功能障碍，Ruscogenin 具有显著的抗炎和抗血栓活性。Ruscogenin 有口服活性。

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Ruscogenin Chemical Structure

Ruscogenin Chemical Structure

CAS No. : 472-11-7

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规格 价格 是否有货 数量
1 mg ￥377
In-stock
5 mg ￥850
In-stock
10 mg ￥1318
In-stock
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Customer Review

Ruscogenin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity[1][2].

IC50 & Target

NLRP3

 

体外研究
(In Vitro)

Ruscogenin (0.01-40 μM；24 小时) 可提高 OGD/R 处理下 bEnd.3 细胞的细胞活力[1]。
Ruscogenin (0.01-10 μM；24 小时) 在经 OGD/R 处理的 bEnd.3 细胞中可恢复内皮细胞屏障渗漏，抑制 IL-Iβ 和 Caspase-1 的表达，并降低 TXNIP/NLRP3 通路信号[1]。
Ruscogenin（0.01-10 μM； 4 小时）在经 OGD/R 处理的 bEnd.3 细胞中可抑制 ROS 的产生，并降低 MAPK 通路的信号[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ruscogenin 相关抗体:

Cell Viability Assay[1]

Cell Line: bEnd.3 cell
Concentration: 0.01 μM, 0.1 μM, 1 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 h
Result: Showed that the cell viability reduction in OGD/R-induced bEnd.3 cell was significantly recovered.

Immunofluorescence[1]

Cell Line: bEnd.3 cell
Concentration: 0.1 μM, 1 μM, 10 μM
Incubation Time: 24 h
Result: Demonstrated increase in the TEER value and inhibition the sodium fluorescein permeability.

Western Blot Analysis[1]

Cell Line: bEnd.3 cell
Concentration: 0.01 μM, 0.1 μM, 1 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 h
Result: Demonstrated downregulation of the expression of IL-1β and Caspase-1 proteins, and inhibition in the expressions of NLRP3 and TXNIP.

Immunofluorescence[1]

Cell Line: bEnd.3 cell
Concentration: 0.01 μM, 0.1 μM, 1 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 4 h
Result: Demonstrated reduction in the production of ROS.
体内研究
(In Vivo)

Ruscogenin (10 mg/kg；灌胃；1次) 改善 MCAO/R 诱导的脑组织损伤，抑制 IL-1β 和 Caspase-1 的表达并抑制TXNIP/NLRP3 的激活[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO/R Mice[1]
Dosage: 10mg/kg
Administration: Oral Gavage (i.g.)
Result: Showed smaller infarct size, ameliorating histopathological damage by decreasing the cell loss, and significant increase in CBF (cerebral blood flow) compared to the model group.
Resulted inhibiting the expression of IL-1β and Caspase-1, NLRP3 and TXNIP compared to the model group.
分子量

430.62

Formula

C27H42O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

鲁斯可皂苷元；螺可吉宁
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.59%

COA (194 KB) HNMR (263 KB) RP-HPLC (243 KB) LCMS (98 KB)

产品使用指南 (1538 KB)
参考文献

Ruscogenin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruscogenin472-11-7鲁斯可皂苷元螺可吉宁NOD-like Receptor (NLR)Cardiovascular DiseaseAnti-inflammationInhibitorinhibitorinhibit

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