1. Anti-infection
    Cell Cycle/DNA Damage
  2. Antibiotic
    Bacterial
    DNA/RNA Synthesis
  3. Sarecycline hydrochloride

Sarecycline hydrochloride 

目录号: HY-13858A 纯度: 98.40%
产品使用指南

Sarecycline hydrochloride 是一种窄谱四环素类抗生素。Sarecycline hydrochloride 具有抗炎作用和对革兰氏阳性菌的有效活性,包括对多种痤疮角质杆菌的活性。Sarecycline hydrochloride 干扰 tRNA 调节并将 mRNA 与 70S 核糖体结合。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Sarecycline hydrochloride Chemical Structure

Sarecycline hydrochloride Chemical Structure

CAS No. : 1035979-44-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥2000 In-stock
10 mg ¥3500 In-stock
50 mg ¥9500 Get quote
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3].

In Vitro

Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms[1].
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2].

In Vivo

Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].

Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
Dosage: 0.33, 1, 3, or 9 mg/kg
Administration: Intravenously
Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
Molecular Weight

523.96

Formula

C₂₄H₃₀ClN₃O₈

CAS No.

1035979-44-2

SMILES

[H]Cl.O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C=CC(CN(C)OC)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SarecyclineAntibioticBacterialDNA/RNA Synthesistetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Sarecycline hydrochloride
目录号:
HY-13858A
需求量: