2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Sarecycline hydrochloride

Sarecycline hydrochloride  (Synonyms: P-005672 hydrochloride)

目录号: HY-13858A 纯度: 98.01%
COA 产品使用指南

摩尔计算器

Sarecycline hydrochloride 是一种口服有效的窄谱四环素衍生物类抗生素。Sarecycline hydrochloride 具有抗炎活性。Sarecycline hydrochloride 能够抑制革兰氏阳性细菌和多种痤疮角质杆菌的活性。Sarecycline hydrochloride 干扰 tRNA 调节并将 mRNA 与 70S 核糖体结合。Sarecycline hydrochloride 能够用于中重度痤疮的研究 。

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Sarecycline hydrochloride Chemical Structure

Sarecycline hydrochloride Chemical Structure

CAS No. : 1035979-44-2

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规格 价格 是否有货 数量
1 mg ￥1800
In-stock
5 mg ￥5200
In-stock
10 mg ￥8060
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Sarecycline hydrochloride:

Sarecycline hydrochloride 相关抗体

Top Publications Citing Use of Products

    Sarecycline hydrochloride purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Sarecycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

    查看 Antibiotic 亚型特异性产品:

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    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne [1][2][3][4][5][6].

    IC50 & Target

    Tetracycline

     

    体外研究
    (In Vitro)

    Sarecycline 抑制 55 株临床分离的痤疮棒状杆菌，其 MIC 值为 0.5~16 µg/ml; MIC50为 0.5 µg/ml, MIC90 为 4µg/ml[1]。
    Sarecycline 对大环内酯耐药的生物体有活性[1]。
    Sarecycline hydrochloride 对肠道需氧革兰氏阴性菌的活性最小[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Sarecycline hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    Sarecycline hydrochloride (0.33-9 mg /kg; 静脉注射) 在小鼠中性粒细胞减少的大腿感染模型中显示出对金黄色葡萄球菌的有效活性[1]。
    Sarecycline 在全身 (腹腔) 感染的 CD-1 小鼠模型中能够抑制金黄色葡萄糖球菌 (PD50=0.25 mg/kg)，但在最高剂量 (>40 mg/kg) 下对大肠杆菌抑制的效果不明显[6]。
    Sarecycline (1-150mg/kg; 腹腔注射; 单剂量) 在 Sprague Dawley 大鼠模型中具有抗炎活性[6]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
    Dosage: 0.33, 1, 3, or 9 mg/kg
    Administration: Intravenously
    Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
    Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
    Clinical Trial
    分子量

    523.96

    Formula

    C24H30ClN3O8
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 100 mg/mL (190.85 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.9085 mL 9.5427 mL 19.0854 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.27%

    COA (199 KB) HNMR (475 KB) RP-HPLC (258 KB) LCMS (95 KB)

    产品使用指南 (1538 KB)
    参考文献

    Sarecycline hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9085 mL 9.5427 mL 19.0854 mL 47.7136 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL 9.5427 mL
    10 mM 0.1909 mL 0.9543 mL 1.9085 mL 4.7714 mL
    15 mM 0.1272 mL 0.6362 mL 1.2724 mL 3.1809 mL
    20 mM 0.0954 mL 0.4771 mL 0.9543 mL 2.3857 mL
    25 mM 0.0763 mL 0.3817 mL 0.7634 mL 1.9085 mL
    30 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5905 mL
    40 mM 0.0477 mL 0.2386 mL 0.4771 mL 1.1928 mL
    50 mM 0.0382 mL 0.1909 mL 0.3817 mL 0.9543 mL
    60 mM 0.0318 mL 0.1590 mL 0.3181 mL 0.7952 mL
    80 mM 0.0239 mL 0.1193 mL 0.2386 mL 0.5964 mL
    100 mM 0.0191 mL 0.0954 mL 0.1909 mL 0.4771 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sarecycline1035979-44-2P-005672P005672P 005672AntibioticBacterialDNA/RNA SynthesisAcneInflammationTetracyclinetetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

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