2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. SOS1-IN-15

SOS1-IN-15 (Compound 37) 是一种具有口服活性的 SOS1 抑制剂，IC50 为 5 nM。SOS1-IN-15 可用于 KRAS 驱动型癌症研究。

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SOS1-IN-15

SOS1-IN-15 Chemical Structure

CAS No. : 2793404-47-2

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SOS1-IN-15 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer[1].

IC50 & Target[1]

SOS1

5 nM (IC50)

体外研究
(In Vitro)

SOS1-IN-15 (Compound 37) (0.1 nM-0.1 mM; 72 h) displays prominent inhibitory activities in Mia-paca-2 cancer cells (IC50 = 178 ± 42 nM)[1].
SOS1-IN-15 has a limited inhibition of CYP and hERG[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SOS1-IN-15 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Mia-paca-2 pancreas cancer cells
Concentration: 0.1 nM-0.1 mM
Incubation Time: 72 h
Result: Inhibited the proliferation with an IC50 of 178 ± 42 nM.
体内研究
(In Vivo)

SOS1-IN-15 (Compound 37) (50 mg/kg; p.o.; daily for 22 days) inhibits tumor volume in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing Mia-paca-2 pancreas tumors[1]
Dosage: 50 mg/kg
Administration: Oral administration, daily for 22 days
Result: Showed 49% tumor inhibition. No animal mortality and significant difference in the mice’s body weight were observed during the study period.
Animal Model: Male CD-1 Mice[1]
Dosage: 20 mg/kg
Administration: Oral administration (Pharmacokinetic Analysis)
Result: In Vivo Pharmacokinetic Properties of the Compounds in Male CD-1 Micea
T1/2 (h) Tmax (h) Cmax (ng/mL) AUC (ng⋅h/mL) MRT (h) Kel (h-1)
SOS1-IN-15 11.4 3.67 1550 9900 4.19 0.25

aCompounds (20 mg/kg) were P.O. dosed in a mixture of 63% water + 30% PEG +5 % DMSO + 2% Tween 80 in male ICR mice (n = 3). Abbreviations: T1/2, elimination half-life; Tmax, plasma peak time after administration; Cmax, maximum plasma concentration; AUC, area under concentration-time curve. MRT, mean residence time; Kel, elimination rate constant.
分子量

536.55

Formula

C28H27F3N6O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMF 中的溶解度 : ≥ 100 mg/mL (186.38 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8638 mL 9.3188 mL 18.6376 mL
5 mM 0.3728 mL 1.8638 mL 3.7275 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SOS1-IN-15 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.8638 mL 9.3188 mL 18.6376 mL 46.5940 mL
5 mM 0.3728 mL 1.8638 mL 3.7275 mL 9.3188 mL
10 mM 0.1864 mL 0.9319 mL 1.8638 mL 4.6594 mL
15 mM 0.1243 mL 0.6213 mL 1.2425 mL 3.1063 mL
20 mM 0.0932 mL 0.4659 mL 0.9319 mL 2.3297 mL
25 mM 0.0746 mL 0.3728 mL 0.7455 mL 1.8638 mL
30 mM 0.0621 mL 0.3106 mL 0.6213 mL 1.5531 mL
40 mM 0.0466 mL 0.2330 mL 0.4659 mL 1.1648 mL
50 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.9319 mL
60 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7766 mL
80 mM 0.0233 mL 0.1165 mL 0.2330 mL 0.5824 mL
100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.4659 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-152793404-47-2Rasorally activeKRAS-driven cancerMia-paca-2BALB/c nude miceInhibitorinhibitorinhibit

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目录号：
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