1. JAK/STAT Signaling Stem Cell/Wnt
  2. STAT
  3. STX-0119

STX-0119 是一种选择性的、具有口服活性的 STAT3 二聚抑制剂。STX-0119 抑制 STAT3 转录,IC50 为 74 μM。

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STX-0119 Chemical Structure

STX-0119 Chemical Structure

CAS No. : 851095-32-4

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1320
In-stock
1 mg ¥545
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5 mg ¥1181
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10 mg ¥1900
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25 mg ¥3800
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50 mg ¥5506
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100 mg ¥7859
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200 mg   询价  
500 mg   询价  

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Customer Review

查看 STAT 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1].

IC50 & Target[1]

STAT3

74 μM (IC50, STAT3 transcription)

体外研究
(In Vitro)

STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells[1].
STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 10, 20 and 50 μM
Incubation Time: 24 h
Result: Reduced the expression of STAT3 target proteins, namely, c-myc, cyclin D1, and survivin, in a concentration-dependent manner. Did not suppress the expression of those STAT3-regulated oncoproteins.
体内研究
(In Vivo)

STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1].
The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/cA-ν/ν nude mice, SCC-3 lymphoma xenograft model[1]
Dosage: 160 mg/kg
Administration: Oral gavage, daily for 4 days
Result: Suppressed the growth of SCC-3 cells significantly on the fourth day.
分子量

382.37

Formula

C22H14N4O3

CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 13.33 mg/mL (34.86 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6153 mL 13.0763 mL 26.1527 mL
5 mM 0.5231 mL 2.6153 mL 5.2305 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STX-0119 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6153 mL 13.0763 mL 26.1527 mL 65.3817 mL
5 mM 0.5231 mL 2.6153 mL 5.2305 mL 13.0763 mL
10 mM 0.2615 mL 1.3076 mL 2.6153 mL 6.5382 mL
15 mM 0.1744 mL 0.8718 mL 1.7435 mL 4.3588 mL
20 mM 0.1308 mL 0.6538 mL 1.3076 mL 3.2691 mL
25 mM 0.1046 mL 0.5231 mL 1.0461 mL 2.6153 mL
30 mM 0.0872 mL 0.4359 mL 0.8718 mL 2.1794 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
STX-0119
目录号:
HY-103692
需求量: