2. Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. HDAC Topoisomerase Apoptosis
  4. Top/HDAC-IN-2

Top/HDAC-IN-2 (45b) 是一种 Top 和 HDAC 的双重抑制剂，具有强大的抗肿瘤活性并诱导细胞凋亡。

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Top/HDAC-IN-2

Top/HDAC-IN-2 Chemical Structure

CAS No. : 2775446-64-3

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Top/HDAC-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].

IC50 & Target

HDAC1

0.004 μM (IC50)

HDAC2

0.005 μM (IC50)

HDAC6

0.15 μM (IC50)

HDAC3

1.10 μM (IC50)

HDAC8

4.5 μM (IC50)

Top1

 

Topoisomerase II

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.23 μM
Compound: 16b
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
[PMID: 37875056]
HCT-116 IC50
0.23 μM
Compound: 16b
Antiproliferative activity against human HCT-116 cells
Antiproliferative activity against human HCT-116 cells
[PMID: 37875056]
HCT-116 IC50
0.23 μM
Compound: 71
Antiproliferative activity against human HCT-116 cells
Antiproliferative activity against human HCT-116 cells
[PMID: 36549115]
MCF7 IC50
0.23 μM
Compound: 16b
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
[PMID: 37875056]
体外研究
(In Vitro)

Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 µM), MCF-7 and A549 cells[1].
Top/HDAC-IN-2 (45b) (0-5 µM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-2.5 µM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Top/HDAC-IN-2 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116
Concentration: 0.1, 2.5 and 5 μM
Incubation Time: 24 h
Result: Arrested the HCT116 cell cycle at the G2 phase in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 0.1, 0.5 and 2.5 μM
Incubation Time: 24 h
Result: Effectively induced the apoptosis in HCT116 cell line in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 1 μM and 5 μM
Incubation Time: 24 h
Result: Concentration-dependently increased the level of acetyl-H3 and acetyl-H4 in HCT116 cells.
分子量

568.63

Formula

C30H32N8O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Top/HDAC-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Top/HDAC-IN-22775446-64-3HDACTopoisomeraseApoptosisHistone deacetylasesHCT116metabolic stabilitiesantitumorInhibitorinhibitorinhibit

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目录号：
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