2. Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. HDAC Topoisomerase Apoptosis
  4. Top/HDAC-IN-2

Top/HDAC-IN-2 (45b) 是一种 Top 和 HDAC 的双重抑制剂，具有强大的抗肿瘤活性并诱导细胞凋亡。

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Top/HDAC-IN-2 Chemical Structure

Top/HDAC-IN-2 Chemical Structure

CAS No. : 2775446-64-3

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Top/HDAC-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].

IC50 & Target

HDAC1

0.004 μM (IC50)

HDAC2

0.005 μM (IC50)

HDAC6

0.15 μM (IC50)

HDAC3

1.10 μM (IC50)

HDAC8

4.5 μM (IC50)

Top1

 

Topoisomerase II

 

体外研究
(In Vitro)

Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 µM), MCF-7 and A549 cells[1].
Top/HDAC-IN-2 (45b) (0-5 µM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-2.5 µM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Top/HDAC-IN-2 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116
Concentration: 0.1, 2.5 and 5 μM
Incubation Time: 24 h
Result: Arrested the HCT116 cell cycle at the G2 phase in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 0.1, 0.5 and 2.5 μM
Incubation Time: 24 h
Result: Effectively induced the apoptosis in HCT116 cell line in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 1 μM and 5 μM
Incubation Time: 24 h
Result: Concentration-dependently increased the level of acetyl-H3 and acetyl-H4 in HCT116 cells.
分子量

568.63

Formula

C30H32N8O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Top/HDAC-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Top/HDAC-IN-22775446-64-3HDACTopoisomeraseApoptosisHistone deacetylasesHCT116metabolic stabilitiesantitumorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-145852
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