1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. TPMPA

TPMPA 是异四氢烟酸和 3-APMPA 的混合物,是 GABAC 的第一个选择性拮抗剂 (KB = 2.1 μM),但不与 GABAA (KB = 320 μM) 或 GABAB (EC50 = 500 μM) 受体相互作用。TPMPA 具有抑制神经节细胞定向选择性的潜力。

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TPMPA Chemical Structure

TPMPA Chemical Structure

CAS No. : 182485-36-5

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生物活性

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].

IC50 & Target

KB: 2.1 μM (GABAC)

体外研究
(In Vitro)

TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1].
TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

161.14

Formula

C6H12NO2P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
TPMPA
目录号:
HY-101359
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